Framework for predicting alloreactivity in hematopoietic cell transplants
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Publisher
Springer Science and Business Media LLC
Link
https://www.nature.com/articles/s41587-024-02354-5.pdf
Reference5 articles.
1. Blazar, B. R., Hill, G. R. & Murphy, W. J. Dissecting the biology of allogeneic HSCT to enhance the GvT effect whilst minimizing GvHD. Nat. Rev. Clin. Oncol. 17, 475–492 (2020). A review of our current understanding of the GvL effect.
2. Shlomchik, W. D. Graft-versus-host disease. Nat. Rev. Immunol. 7, 340–352 (2007). A review that provides mechanistic insights into GvHD immunobiology.
3. Biernacki, M. A., Sheth, V. S. & Bleakley, M. T cell optimization for graft-versus-leukemia responses. JCI Insight 5, e134939 (2020). A review that describes the alloantigenic and antigenic landscapes after transplant as well as strategies to augment the GvL effect.
4. Griffioen, M., van Bergen, C. A. & Falkenburg, J. H. Autosomal minor histocompatibility antigens: how genetic variants create diversity in immune targets. Front. Immunol. 7, 100 (2016). A review that provides a comprehensive compendium of known mHAgs.
5. Mutis, T., Xagara, A. & Spaapen, R. M. The connection between minor H antigens and neoantigens and the missing link in their prediction. Front. Immunol. 11, 1162 (2020). A review that establishes a fascinating parallelism between neoantigens and mHAgs.
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