Dynamic bias and its implications for GPCR drug discovery
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
http://www.nature.com/articles/nrd3954-c3.pdf
Reference17 articles.
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3. Maack, C. et al. Characterization of β1-selectivity, adrenoceptor-Gs-protein interaction and inverse agonism of nebivolol in human myocardium. Br. J. Pharmacol. 132, 1817–1826 (2001).
4. Galandrin, S. & Bouvier, M. Distinct signaling profiles of β1 and β2 adrenergic receptor ligands towards adenylyl cyclase and mitogen-activated protein kinase reveals pluridimensionality of efficacy. Mol. Pharmacol. 70, 1575–1584 (2006).
5. Brodde, O. -E. & Michel, M. C. Adrenergic and muscarinic receptors in the human heart. Pharmacol. Rev. 51, 651–689 (1999).
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