10-year safety follow-up in patients with local VEGF gene transfer to ischemic lower limb
Author:
Publisher
Springer Science and Business Media LLC
Subject
Genetics,Molecular Biology,Molecular Medicine
Link
http://www.nature.com/articles/gt2011109.pdf
Reference33 articles.
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2. Tongers J, Roncalli J, Losordo D . Therapeutic angiogenesis for critical limb ischemia, microvascular therapies coming of age. Circulation 2008; 118: 9–16.
3. Hedman M, Hartikainen J, Syvänne M, Stjernvall J, Hedman A, Kivelä A et al. Safety and feasibility of catheter-based local intracoronary vascular endothelial growth factor gene transfer in the prevention of postangioplasty and in-stent restenosis and in the treatment of chronic myocardial ischemia: phase II results of the Kuopio Angiogenesis Trial (KAT). Circulation 2003; 107: 2677–2683.
4. Mäkinen K, Manninen H, Hedman M, Matsi P, Mussalo H, Alhava E et al. Increased vascularity detected by digital subtraction angiography after VEGF gene transfer to human lower limb artery: a randomized, placebo-controlled, double-blinded phase II study. Mol Ther 2002; 6: 127–133.
5. Amano H, Hackett NR, Kaner RJ, Whitlock P, Rosengart TK, Crystal RJ . Alteration of splicing signals in a genomic/cDNA hybrid VEGF gene to modify the ratio of expressed VEGF isoforms enhances safety of angiogenic gene therapy. Mol Ther 2005; 12: 715–724.
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