RNAi-mediated knockdown of HMG CoA reductase enhances gene expression from physiologically regulated low-density lipoprotein receptor therapeutic vectors in vivo-Reference-Cited by-同舟云学术

RNAi-mediated knockdown of HMG CoA reductase enhances gene expression from physiologically regulated low-density lipoprotein receptor therapeutic vectors in vivo

Published:2011-07-28 Issue:4 Volume:19 Page:463-467
ISSN:0969-7128
Container-title:Gene Therapy
language:en
Short-container-title:Gene Ther

Author:

Hibbitt O,Agkatsev S,Owen C,Cioroch M,Seymour L,Channon K,Wade-Martins R

Publisher

Springer Science and Business Media LLC

Subject

Genetics,Molecular Biology,Molecular Medicine

Link

http://www.nature.com/articles/gt2011103.pdf

Reference25 articles.

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2. Grossman M, Rader DJ, Muller DW, Kolansky DM, Kozarsky K, Clark III BJ et al. A pilot study of ex vivo gene therapy for homozygous familial hypercholesterolaemia. Nat Med 1995; 1: 1148–1154.

3. Miyanohara A, Sharkey MF, Witztum JL, Steinberg D, Friedmann T . Efficient expression of retroviral vector-transduced human low density lipoprotein (LDL) receptor in LDL receptor-deficient rabbit fibroblasts in vitro. Proc Natl Acad Sci USA 1988; 85: 6538–6542.

4. Wilson JM, Johnston DE, Jefferson DM, Mulligan RC . Correction of the genetic defect in hepatocytes from the Watanabe heritable hyperlipidemic rabbit. Proc Natl Acad Sci USA 1988; 85: 4421–4425.

5. Kankkonen HM, Vahakangas E, Marr RA, Pakkanen T, Laurema A, Leppanen P et al. Long-term lowering of plasma cholesterol levels in LDL-receptor-deficient WHHL rabbits by gene therapy. Mol Ther 2004; 9: 548–556.

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