Whole-genome analyses of whole-brain data: working within an expanded search space
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Neuroscience
Link
http://www.nature.com/articles/nn.3718.pdf
Reference69 articles.
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3. Stein, J.L. et al. Identification of common variants associated with human hippocampal and intracranial volumes. Nat. Genet. 44, 552–561 (2012). This paper, along with three others published simultaneously, reported the first large-scale imaging genetics studies. Analyzing scans from over 20,000 individuals in aggregate, measures derived from brain images were shown to be viable and promising traits for genome-wide search. Successful GWAS discoveries were replicated among the collaborating consortia.
4. Bis, J.C. et al. Common variants at 12q14 and 12q24 are associated with hippocampal volume. Nat. Genet. 44, 545–551 (2012).
5. Strittmatter, W.J. et al. Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc. Natl. Acad. Sci. USA 90, 1977–1981 (1993). Genetically informed priors were used to pinpoint ApoE4 as a risk haplotype associated with late-onset Alzheimer's disease. Twenty years later, this is perhaps the disease risk allele with the highest odds ratio for any common neurological disorder. Neuroimaging studies have since mapped the effects of ApoE4 on various brain traits (volume differences, cortical thinning patterns, shape variations, white matter pathology, etc.) in many cohorts of young and elderly individuals.
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