Rethinking JAK2 inhibition: towards novel strategies of more specific and versatile janus kinase inhibition
Author:
Publisher
Springer Science and Business Media LLC
Subject
Oncology,Cancer Research,Hematology
Link
https://www.nature.com/articles/leu201743.pdf
Reference104 articles.
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2. Briscoe J, Rogers NC, Witthuhn BA, Watling D, Harpur AG, Wilks AF et al. Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state. EMBO J 1996; 15: 799–809.
3. Drachman JG, Millett KM, Kaushansky K . Thrombopoietin signal transduction requires functional JAK2, not TYK2. J Biol Chem 1999; 274: 13480–13484.
4. Witthuhn BA, Quelle FW, Silvennoinen O, Yi T, Tang B, Miura O et al. JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin. Cell 1993; 74: 227–236.
5. Royer Y, Staerk J, Costuleanu M, Courtoy PJ, Constantinescu SN . Janus kinases affect thrombopoietin receptor cell surface localization and stability. J Biol Chem 2005; 280: 27251–27261.
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