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AAV Vector–mediated RNAi of Mutant Huntingtin Expression Is Neuroprotective in a Novel Genetic Rat Model of Huntington's Disease

  • Published:2008-05 Issue:5 Volume:16 Page:947-956
  • ISSN:1525-0016
  • Container-title:Molecular Therapy
  • language:en
  • Short-container-title:Molecular Therapy

Author:

Franich Nicholas R,Fitzsimons Helen L,Fong Dahna M,Klugmann Matthias,During Matthew J,Young Deborah

Publisher

Elsevier BV

Subject

Drug Discovery,Pharmacology,Genetics,Molecular Biology,Molecular Medicine

Reference47 articles.

1. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes;The Huntington's Disease Collaborative Research Group;Cell,1993

2. Trinucleotide repeat disorders;Orr;Annu Rev Neurosci,2007

3. Huntington disease;Vonsattel;J Neuropathol Exp Neurol,1998

4. Mouse models of Huntington's disease;Menalled;Trends Pharmacol Sci,2002

5. Viral-based gene transfer to the mammalian CNS for functional genomic studies;Janson;Trends Neurosci,2001

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