Body composition of infants at 6 months of age using a 3-compartment model
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Published:2023-10-13
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Volume:
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ISSN:0954-3007
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Container-title:European Journal of Clinical Nutrition
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language:en
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Short-container-title:Eur J Clin Nutr
Author:
Kuriyan RebeccaORCID, Hills Andrew P.ORCID, Murphy-Alford AlexiaORCID, Padmanabha Ramya, Nyati Lukhanyo H.ORCID, Byrne Nuala M., Kurpad Anura V.ORCID, Norris ShaneORCID, Ariff Shabina, Santos Ina S., Wickramasinghe V. Pujitha, Murphy-Alford Alexia J., Nyati Lukhanyo, Costa Caroline S., Lucas Nishani, Ahmad Tanvir, Ahuja Kiran D. K., Beckett Jeffrey M., Bielemann Renata M., Charania Laila, Christian Michele P., Divya Priscilla J., Hanley Anne, Herath Manoja P., Ismail Leila C., Jayasinghe Sisitha, Lanerolle Pulani, Loechl Cornelia, Moktar Najat, Senerath Upul, Slater Christine, Soofi Sajid, Street Steven J., Valle Neiva C. J., Yameen Ayesha,
Abstract
Abstract
Background/Objectives
Two compartment (2 C) models of body composition, including Air Displacement Plethysmography (ADP) and Deuterium Dilution (DD), assume constant composition of fat-free mass (FFM), while 3-compartment (3 C) model overcomes some of these assumptions; studies are limited in infants. The objective of the present study is to compare 3 C estimates of body composition in 6-mo. old infants from Australia, India, and South Africa, including FFM density and hydration, compare with published literature and to evaluate agreement of body composition estimates from ADP and DD.
Methods
Body volume and water were measured in 176 healthy infants using ADP and DD. 3C-model estimates of fat mass (FM), FFM and its composition were calculated, compared between countries (age and sex adjusted) and with published literature. Agreement between estimates from ADP and DD were compared by Bland–Altman and correlation analyses.
Results
South African infants had significantly higher % FM (11.5%) and density of FFM compared to Australian infants. Australian infants had significantly higher % FFM (74.7 ± 4.4%) compared to South African infants (71.4 ± 5.0) and higher FFMI (12.7 ± 0.8 kg/m2) compared to South African (12.3 ± 1.2 kg/m2) and Indian infants (11.9 ± 1.0 kg/m2). FFM composition of present study differed significantly from literature. Pooled three country estimates of FM and FFM were comparable between ADP and DD; mean difference of −0.05 (95% CI: −0.64, +0.55) kg and +0.05 (95% CI: −0.55, +0.64) kg.
Conclusions
3C-model estimates of body composition in infants differed between countries; future studies are needed to confirm these findings and investigate causes for the differences.
Funder
Bill and Melinda Gates Foundation International Atomic Energy Agency, Grant reference number- CRP E43028
Publisher
Springer Science and Business Media LLC
Subject
Nutrition and Dietetics,Medicine (miscellaneous)
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