The impact of proinflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes-Reference-Cited by-同舟云学术

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The impact of proinflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes

Published:2019-11 Issue:11 Volume:51 Page:1588-1595
ISSN:1061-4036
Container-title:Nature Genetics
language:en
Short-container-title:Nat Genet

Author:

Ramos-Rodríguez Mireia^ORCID,Raurell-Vila Helena,Colli Maikel L.,Alvelos Maria Inês,Subirana-Granés Marc,Juan-Mateu Jonàs,Norris Richard,Turatsinze Jean-Valery,Nakayasu Ernesto S.^ORCID,Webb-Robertson Bobbie-Jo M.,Inshaw Jamie R. J.,Marchetti Piero,Piemonti Lorenzo^ORCID,Esteller Manel,Todd John A.,Metz Thomas O.,Eizirik Décio L.,Pasquali Lorenzo^ORCID

Funder

Ministry of Economy and Competitiveness | Agencia Estatal de Investigación

Fundació la Marató de TV3

Ministry of Economy and Competitiveness | Instituto de Salud Carlos III

Ministerio de Economía y Competitividad

U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Fédération Wallonie-Bruxelles

Innovative Medicines Initiative

JDRF

Publisher

Springer Science and Business Media LLC

Subject

Genetics

Link

http://www.nature.com/articles/s41588-019-0524-6.pdf

Reference83 articles.

1. Todd, J. A. Etiology of type 1 diabetes. Immunity 32, 457–467 (2010).

2. Ziegler, A.-G. & Nepom, G. T. Prediction and pathogenesis in type 1 diabetes. Immunity 32, 468–478 (2010).

3. Eizirik, D. L., Colli, M. L. & Ortis, F. The role of inflammation in insulitis and β-cell loss in type 1 diabetes. Nat. Rev. Endocrinol. 5, 219–226 (2009).

4. Onengut-Gumuscu, S. et al. Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers. Nat. Genet. 47, 381–386 (2015).

5. Farh, K. K. et al. Genetic and epigenetic fine mapping of causal autoimmune disease variants. Nature 518, 337–343 (2015).

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