A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation
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Published:2022-06
Issue:6
Volume:54
Page:761-771
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ISSN:1061-4036
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Container-title:Nature Genetics
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language:en
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Short-container-title:Nat Genet
Author:
Vujkovic MarijanaORCID, Ramdas Shweta, Lorenz Kim M.ORCID, Guo XiuqingORCID, Darlay Rebecca, Cordell Heather J.ORCID, He Jing, Gindin Yevgeniy, Chung Chuhan, Myers Robert P., Schneider Carolin V., Park JosephORCID, Lee Kyung MinORCID, Serper Marina, Carr Rotonya M., Kaplan David E.ORCID, Haas Mary E., MacLean Matthew T., Witschey Walter R.ORCID, Zhu XiangORCID, Tcheandjieu CatherineORCID, Kember Rachel L.ORCID, Kranzler Henry R.ORCID, Verma Anurag, Giri AyushORCID, Klarin Derek M.ORCID, Sun Yan V.ORCID, Huang JieORCID, Huffman Jennifer E.ORCID, Creasy Kate TownsendORCID, Hand Nicholas J.ORCID, Liu Ching-TiORCID, Long Michelle T., Yao Jie, Budoff MatthewORCID, Tan Jingyi, Li Xiaohui, Lin Henry J.ORCID, Chen Yii-Der Ida, Taylor Kent D., Chang Ruey-Kang, Krauss Ronald M., Vilarinho SilviaORCID, Brancale Joseph, Nielsen Jonas B., Locke Adam E.ORCID, Jones Marcus B., Verweij Niek, Baras ArisORCID, Reddy K. Rajender, Neuschwander-Tetri Brent A.ORCID, Schwimmer Jeffrey B., Sanyal Arun J., Chalasani Naga, Ryan Kathleen A.ORCID, Mitchell Braxton D., Gill DipenderORCID, Wells Andrew D., Manduchi ElisabettaORCID, Saiman Yedidya, Mahmud Nadim, Miller Donald R.ORCID, Reaven Peter D.ORCID, Phillips Lawrence S.ORCID, Muralidhar Sumitra, DuVall Scott L.ORCID, Lee Jennifer S., Assimes Themistocles L.ORCID, Pyarajan Saiju, Cho Kelly, Edwards Todd L.ORCID, Damrauer Scott M.ORCID, Wilson Peter W., Gaziano J. Michael, O’Donnell Christopher J.ORCID, Khera Amit V.ORCID, Grant Struan F. A.ORCID, Brown Christopher D., Tsao Philip S.ORCID, Saleheen DanishORCID, Lotta Luca A., Bastarache Lisa, Anstee Quentin M., Daly Ann K., Meigs James B., Rotter Jerome I., Lynch Julie A.ORCID, Rader Daniel J.ORCID, Voight Benjamin F.ORCID, Chang Kyong-MiORCID, , , ,
Publisher
Springer Science and Business Media LLC
Reference109 articles.
1. Asrani, S. K., Devarbhavi, H., Eaton, J. & Kamath, P. S. Burden of liver diseases in the world. J. Hepatol. 70, 151–171 (2019). 2. Younossi, Z., Anstee, Q. M. & Marietti, M. Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention. Nat. Rev. Gastroenterol. Hepatol. 15, 11–20 (2018). 3. Estes, C., Razavi, H., Loomba, R., Younossi, Z. & Sanyal, A. J. Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease. Hepatology 67, 123–133 (2018). 4. Carr, R. M., Oranu, A. & Khungar, V. Nonalcoholic fatty liver disease: pathophysiology and management. Gastroenterol. Clin. North Am. 45, 639–652 (2016). 5. Chalasani, N. et al. The diagnosis and management of nonalcoholic fatty liver disease: practice guidance from the American Association for the Study of Liver Diseases. Hepatology 67, 328–357 (2018).
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