A lncRNA–chromatin circuit regulates IL-1β-driven inflammation
Author:
Publisher
Springer Science and Business Media LLC
Subject
Genetics
Link
https://www.nature.com/articles/s41588-023-01605-6.pdf
Reference5 articles.
1. Arts, R. J. W. et al. BCG vaccination protects against experimental viral infection in humans through the induction of cytokines associated with trained immunity. Cell Host Microbe 23, 89–100.e105 (2018). This paper demonstrates that trained immunity underlies BCG-induced protection against heterologous viral pathogens with the involvement of IL-1β and the rs16944 SNP.
2. Kaufmann, E. et al. BCG educates hematopoietic stem cells to generate protective innate immunity against tuberculosis. Cell 172, 176–190.e119 (2018). This paper highlights epigenetically reprogrammed hematopoietic stem cells as the source of trained immunity.
3. Jimenez-Sousa, M. A. et al. IL-1β rs16944 polymorphism is related to septic shock and death. Eur. J. Clin. Invest. 47, 53–62 (2017). This paper linked an rs16944 variant (rs16944 A) with septic shock and death.
4. Mattick, J. S. et al. Long non-coding RNAs: definitions, functions, challenges and recommendations. Nat. Rev. Mol. Cell Biol. 24, 430–447 (2023). This review comprehensively summarizes known functions of lncRNAs.
5. Cavalli, G. et al. The anti-inflammatory cytokine interleukin-37 is an inhibitor of trained immunity. Cell Rep. 35, 108955 (2021). This paper highlights IL-37 as an anti-inflammatory cytokine that negatively regulates IL-1β signaling and trained immunity.
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