Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility
-
Published:2022-02-24
Issue:3
Volume:54
Page:232-239
-
ISSN:1061-4036
-
Container-title:Nature Genetics
-
language:en
-
Short-container-title:Nat Genet
Author:
Barc JulienORCID, Tadros RafikORCID, Glinge Charlotte, Chiang David Y.ORCID, Jouni Mariam, Simonet Floriane, Jurgens Sean J.ORCID, Baudic Manon, Nicastro MicheleORCID, Potet Franck, Offerhaus Joost A., Walsh RoddyORCID, Choi Seung HoanORCID, Verkerk Arie O.ORCID, Mizusawa Yuka, Anys Soraya, Minois Damien, Arnaud Marine, Duchateau Josselin, Wijeyeratne Yanushi D., Muir Alison, Papadakis Michael, Castelletti Silvia, Torchio Margherita, Ortuño Cristina GilORCID, Lacunza Javier, Giachino Daniela F.ORCID, Cerrato Natascia, Martins Raphaël P., Campuzano OscarORCID, Van Dooren Sonia, Thollet Aurélie, Kyndt Florence, Mazzanti Andrea, Clémenty Nicolas, Bisson ArnaudORCID, Corveleyn Anniek, Stallmeyer Birgit, Dittmann Sven, Saenen Johan, Noël Antoine, Honarbakhsh Shohreh, Rudic Boris, Marzak Halim, Rowe Matthew K., Federspiel Claire, Le Page Sophie, Placide Leslie, Milhem Antoine, Barajas-Martinez HectorORCID, Beckmann Britt-MariaORCID, Krapels Ingrid P., Steinfurt Johannes, Winkel Bo Gregers, Jabbari Reza, Shoemaker Moore B., Boukens Bas J., Škorić-Milosavljević Doris, Bikker Hennie, Manevy Federico, Lichtner Peter, Ribasés Marta, Meitinger Thomas, Müller-Nurasyid MartinaORCID, Strauch Konstantin, Peters Annette, Schulz Holger, Schwettmann Lars, Leidl Reiner, Heier Margit, Veldink Jan H.ORCID, van den Berg Leonard H., Van Damme PhilipORCID, Cusi Daniele, Lanzani Chiara, Rigade Sidwell, Charpentier Eric, Baron EstelleORCID, Bonnaud Stéphanie, Lecointe SimonORCID, Donnart Audrey, Le Marec Hervé, Chatel Stéphanie, Karakachoff Matilde, Bézieau StéphaneORCID, London Barry, Tfelt-Hansen Jacob, Roden Dan, Odening Katja E., Cerrone Marina, Chinitz Larry A., Volders Paul G., van de Berg Maarten P.ORCID, Laurent Gabriel, Faivre Laurence, Antzelevitch Charles, Kääb Stefan, Arnaout Alain Al, Dupuis Jean-Marc, Pasquie Jean-Luc, Billon Olivier, Roberts Jason D., Jesel Laurence, Borggrefe Martin, Lambiase Pier D., Mansourati Jacques, Loeys Bart, Leenhardt Antoine, Guicheney Pascale, Maury Philippe, Schulze-Bahr Eric, Robyns Tomas, Breckpot JeroenORCID, Babuty Dominique, Priori Silvia G., Napolitano CarloORCID, Defaye Pascal, Anselme Frédéric, Darmon Jean Philippe, Wiart François, de Asmundis CarloORCID, Brugada Pedro, Brugada Ramon, Arbelo ElenaORCID, Brugada Josep, Mabo Philippe, Behar Nathalie, Giustetto Carla, Molina Maria SabaterORCID, Gimeno Juan R., Hasdemir Can, Schwartz Peter J.ORCID, Crotti Lia, McKeown Pascal P.ORCID, Sharma Sanjay, Behr Elijah R.ORCID, Haissaguerre Michel, Sacher Frédéric, Rooryck Caroline, Tan Hanno L., Remme Carol A., Postema Pieter G., Delmar Mario, Ellinor Patrick T.ORCID, Lubitz Steven A.ORCID, Gourraud Jean-Baptiste, Tanck Michael W.ORCID, George Alfred L.ORCID, MacRae Calum A., Burridge Paul W.ORCID, Dina ChristianORCID, Probst Vincent, Wilde Arthur A., Schott Jean-JacquesORCID, Redon RichardORCID, Bezzina Connie R.ORCID, ,
Publisher
Springer Science and Business Media LLC
Reference69 articles.
1. Brugada, P. & Brugada, J. Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report. J. Am. Coll. Cardiol. 20, 1391–1396 (1992). 2. Priori, S. G. et al. 2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: The Task Force for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death of the European Society of Cardiology (ESC). Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC). Eur. Heart J. 36, 2793–2867 (2015). 3. Chen, Q. et al. Genetic basis and molecular mechanism for idiopathic ventricular fibrillation. Nature 392, 293–296 (1998). 4. Le Scouarnec, S. et al. Testing the burden of rare variation in arrhythmia-susceptibility genes provides new insights into molecular diagnosis for Brugada syndrome. Hum. Mol. Genet. 24, 2757–2763 (2015). 5. Bezzina, C. R. et al. Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death. Nat. Genet. 45, 1044–1049 (2013).
Cited by
50 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
|
|