Mapping the dynamic genetic regulatory architecture of HLA genes at single-cell resolution
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Published:2023-11-30
Issue:12
Volume:55
Page:2255-2268
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ISSN:1061-4036
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Container-title:Nature Genetics
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language:en
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Short-container-title:Nat Genet
Author:
Kang Joyce B., Shen Amber Z., Gurajala Saisriram, Nathan AparnaORCID, Rumker Laurie, Aguiar Vitor R. C.ORCID, Valencia Cristian, Lagattuta Kaitlyn A., Zhang FanORCID, Jonsson Anna HelenaORCID, Yazar Seyhan, Alquicira-Hernandez Jose, Khalili Hamed, Ananthakrishnan Ashwin N., Jagadeesh KarthikORCID, Dey KushalORCID, Albrecht Jennifer, Apruzzese William, Banda Nirmal, Barnas Jennifer L., Bathon Joan M., Ben-Artzi Ami, Boyce Brendan F., Boyle David L., Bridges S. Louis, Bykerk Vivian P., Campbell Debbie, Carr Hayley L., Ceponis Arnold, Chicoine Adam, Cordle Andrew, Curtis Michelle, Deane Kevin D., DiCarlo Edward, Dunn Patrick, Filer Andrew, Firestein Gary S., Forbess Lindsy, Geraldino-Pardilla Laura, Goodman Susan M., Gravallese Ellen M., Gregersen Peter K., Guthridge Joel M., Holers V. Michael, Horowitz Diane, Hughes Laura B., Ishigaki Kazuyoshi, Ivashkiv Lionel B., James Judith A., Keras Gregory, Korsunsky Ilya, Lakhanpal Amit, Lederer James A., Lewis Myles, Li Zhihan J., Li Yuhong, Liao Katherine P., Mandelin Arthur M., Mantel Ian, Marks Kathryne E., Maybury Mark, McDavid Andrew, McGeachy Mandy J., Mears Joseph, Meednu Nida, Millard Nghia, Moreland Larry W., Nayar Saba, Nerviani Alessandra, Orange Dana E., Perlman Harris, Pitzalis Costantino, Rangel-Moreno Javier, Raza Karim, Reshef Yakir, Ritchlin Christopher, Rivellese Felice, Robinson William H., Sahbudin Ilfita, Singaraju Anvita, Seifert Jennifer A., Slowikowski Kamil, Smith Melanie H., Tabechian Darren, Scheel-Toellner Dagmar, Utz Paul J., Watts Gerald F. M., Wei Kevin, Weinand Kathryn, Weisenfeld Dana, Weisman Michael H., Wyse Aaron, Xiao Qian, Zhu Zhu, Daly Mark J., Xavier Ramnik J., Donlin Laura T., Anolik Jennifer H., Powell Joseph E.ORCID, Rao Deepak A.ORCID, Brenner Michael B.ORCID, Gutierrez-Arcelus MariaORCID, Luo YangORCID, Sakaue Saori, Raychaudhuri SoumyaORCID,
Funder
U.S. Department of Health & Human Services | National Institutes of Health MGH Center for the Study of Inflammatory Bowel Disease Fok Foundation Arthritis National Research Foundation Gilead Sciences Lupus Research Alliance Kennedy Trust KTRR Senior Research Fellowship
Publisher
Springer Science and Business Media LLC
Reference81 articles.
1. Lenz, T. L., Spirin, V., Jordan, D. M. & Sunyaev, S. R. Excess of deleterious mutations around HLA genes reveals evolutionary cost of balancing selection. Mol. Biol. Evol. 33, 2555–2564 (2016). 2. Dendrou, C. A., Petersen, J., Rossjohn, J. & Fugger, L. HLA variation and disease. Nat. Rev. Immunol. 18, 325–339 (2018). 3. Matzaraki, V., Kumar, V., Wijmenga, C. & Zhernakova, A. The MHC locus and genetic susceptibility to autoimmune and infectious diseases. Genome Biol. 18, 76 (2017). 4. Trowsdale, J. & Knight, J. C. Major histocompatibility complex genomics and human disease. Annu. Rev. Genomics Hum. Genet. 14, 301–323 (2013). 5. Okada, Y. et al. Fine mapping major histocompatibility complex associations in psoriasis and its clinical subtypes. Am. J. Hum. Genet. 95, 162–172 (2014).
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