Genes with immune functions modulate key traits associated with Down syndrome in mice
Author:
Publisher
Springer Science and Business Media LLC
Subject
Genetics
Link
https://www.nature.com/articles/s41588-023-01400-3.pdf
Reference6 articles.
1. Antonarakis, S. E. et al. Down syndrome. Nat. Rev. Dis. Primers 6, 9 (2020). A review article summarizing the current state of Down syndrome research.
2. Li, Z. et al. Duplication of the entire 22.9 Mb human chromosome 21 syntenic region on mouse chromosome 16 causes cardiovascular and gastrointestinal abnormalities. Hum. Mol. Genet. 16, 1359–1366 (2007). A paper describing the Dp16 mouse model of Down syndrome.
3. Tan, Y. H. et al. Human chromosome 21 dosage: effect on the expression of the interferon induced antiviral state. Science 186, 61–63 (1974). A pioneering paper demonstrating that cells with trisomy 21 are hypersensitive to interferon stimulation.
4. Maroun, L. E. Interferon action and chromosome 21 trisomy. J. Theor. Biol. 86, 603–606 (1980). An early review article on the potential role of interferon signaling in Down syndrome.
5. Sullivan, K. D. et al. Trisomy 21 consistently activates the interferon response. eLife 5, e162020 (2016). A paper describing consistent upregulation of interferon signaling in multiple immune and non-immune cell types with trisomy 21.
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