Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations
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Published:2019-02-25
Issue:3
Volume:51
Page:494-505
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ISSN:1061-4036
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Container-title:Nature Genetics
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language:en
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Short-container-title:Nat Genet
Author:
Sakornsakolpat PhuwanatORCID, , Prokopenko DmitryORCID, Lamontagne Maxime, Reeve Nicola F., Guyatt Anna L.ORCID, Jackson Victoria E., Shrine NickORCID, Qiao Dandi, Bartz Traci M., Kim Deog Kyeom, Lee Mi Kyeong, Latourelle Jeanne C., Li Xingnan, Morrow Jarrett D., Obeidat Ma’enORCID, Wyss Annah B., Bakke Per, Barr R. Graham, Beaty Terri H.ORCID, Belinsky Steven A., Brusselle Guy G., Crapo James D., de Jong KimORCID, DeMeo Dawn L., Fingerlin Tasha E., Gharib Sina A., Gulsvik Amund, Hall Ian P., Hokanson John E., Kim Woo Jin, Lomas David A., London Stephanie J.ORCID, Meyers Deborah A., O’Connor George T., Rennard Stephen I., Schwartz David A.ORCID, Sliwinski Pawel, Sparrow David, Strachan David P.ORCID, Tal-Singer RuthORCID, Tesfaigzi Yohannes, Vestbo Jørgen, Vonk Judith M., Yim Jae-Joon, Zhou Xiaobo, Bossé Yohan, Manichaikul Ani, Lahousse LiesORCID, Silverman Edwin K., Boezen H. Marike, Wain Louise V., Tobin Martin D.ORCID, Hobbs Brian D.ORCID, Cho Michael H.ORCID,
Publisher
Springer Science and Business Media LLC
Reference125 articles.
1. GBD 2015 Chronic Respiratory Disease Collaborators. Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet Respir. Med. 5, 691–706 (2017). 2. World Health Organization. Global Health Estimates 2016: Disease burden by Cause, Age, Sex, by Country and by Region, 2000–2016.
https://www.who.int/healthinfo/global_burden_disease/estimates/en/index1.html
(2018). 3. Fuchsberger, C. et al. The genetic architecture of type 2 diabetes. Nature 536, 41–47 (2016). 4. Zhou, J. J. et al. Heritability of chronic obstructive pulmonary disease and related phenotypes in smokers. Am. J. Respir. Crit. Care Med. 188, 941–947 (2013). 5. Hobbs, B. D. et al. Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis. Nat. Genet. 49, 426–432 (2017).
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