Integrating genetics with single-cell multiomic measurements across disease states identifies mechanisms of beta cell dysfunction in type 2 diabetes
Author:
Funder
U.S. Department of Health & Human Services | National Institutes of Health
Publisher
Springer Science and Business Media LLC
Subject
Genetics
Link
https://www.nature.com/articles/s41588-023-01397-9.pdf
Reference63 articles.
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3. Dominguez-Gutierrez, G., Xin, Y. & Gromada, J. Heterogeneity of human pancreatic β-cells. Mol. Metab. 27, S7–S14 (2019).
4. Benninger, R. K. P. & Kravets, V. The physiological role of β-cell heterogeneity in pancreatic islet function. Nat. Rev. Endocrinol. 18, 9–22 (2022).
5. Segerstolpe, Å. et al. Single-cell transcriptome profiling of human pancreatic islets in health and type 2 diabetes. Cell Metab. 24, 593–607 (2016).
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