Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation-Reference-Cited by-同舟云学术

Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

Published:2022-05 Issue:5 Volume:54 Page:560-572
ISSN:1061-4036
Container-title:Nature Genetics
language:en
Short-container-title:Nat Genet

Author:

Mahajan Anubha^ORCID,Spracklen Cassandra N.,Zhang Weihua^ORCID,Ng Maggie C. Y.^ORCID,Petty Lauren E.,Kitajima Hidetoshi,Yu Grace Z.,Rüeger Sina^ORCID,Speidel Leo,Kim Young Jin^ORCID,Horikoshi Momoko,Mercader Josep M.^ORCID,Taliun Daniel,Moon Sanghoon,Kwak Soo-Heon,Robertson Neil R.,Rayner Nigel W.,Loh Marie,Kim Bong-Jo,Chiou Joshua,Miguel-Escalada Irene^ORCID,della Briotta Parolo Pietro,Lin Kuang,Bragg Fiona,Preuss Michael H.,Takeuchi Fumihiko,Nano Jana,Guo Xiuqing,Lamri Amel,Nakatochi Masahiro,Scott Robert A.,Lee Jung-Jin,Huerta-Chagoya Alicia,Graff Mariaelisa,Chai Jin-Fang,Parra Esteban J.,Yao Jie,Bielak Lawrence F.,Tabara Yasuharu,Hai Yang,Steinthorsdottir Valgerdur,Cook James P.,Kals Mart,Grarup Niels,Schmidt Ellen M.,Pan Ian,Sofer Tamar,Wuttke Matthias,Sarnowski Chloe,Gieger Christian,Nousome Darryl,Trompet Stella,Long Jirong,Sun Meng,Tong Lin,Chen Wei-Min,Ahmad Meraj,Noordam Raymond,Lim Victor J. Y.,Tam Claudia H. T.,Joo Yoonjung Yoonie,Chen Chien-Hsiun,Raffield Laura M.,Lecoeur Cécile,Prins Bram Peter,Nicolas Aude,Yanek Lisa R.,Chen Guanjie,Jensen Richard A.,Tajuddin Salman,Kabagambe Edmond K.,An Ping,Xiang Anny H.,Choi Hyeok Sun,Cade Brian E.,Tan Jingyi,Flanagan Jack,Abaitua Fernando,Adair Linda S.,Adeyemo Adebowale,Aguilar-Salinas Carlos A.,Akiyama Masato,Anand Sonia S.,Bertoni Alain,Bian Zheng,Bork-Jensen Jette,Brandslund Ivan,Brody Jennifer A.,Brummett Chad M.,Buchanan Thomas A.,Canouil Mickaël,Chan Juliana C. N.,Chang Li-Ching,Chee Miao-Li,Chen Ji,Chen Shyh-Huei,Chen Yuan-Tsong,Chen Zhengming,Chuang Lee-Ming,Cushman Mary,Das Swapan K.,de Silva H. Janaka,Dedoussis George,Dimitrov Latchezar,Doumatey Ayo P.,Du Shufa,Duan Qing,Eckardt Kai-Uwe,Emery Leslie S.,Evans Daniel S.,Evans Michele K.,Fischer Krista,Floyd James S.,Ford Ian,Fornage Myriam,Franco Oscar H.,Frayling Timothy M.,Freedman Barry I.,Fuchsberger Christian,Genter Pauline,Gerstein Hertzel C.,Giedraitis Vilmantas,González-Villalpando Clicerio,González-Villalpando Maria Elena,Goodarzi Mark O.,Gordon-Larsen Penny,Gorkin David,Gross Myron,Guo Yu,Hackinger Sophie,Han Sohee,Hattersley Andrew T.,Herder Christian,Howard Annie-Green,Hsueh Willa,Huang Mengna,Huang Wei,Hung Yi-Jen,Hwang Mi Yeong,Hwu Chii-Min,Ichihara Sahoko,Ikram Mohammad Arfan,Ingelsson Martin,Islam Md Tariqul,Isono Masato,Jang Hye-Mi,Jasmine Farzana,Jiang Guozhi,Jonas Jost B.,Jørgensen Marit E.,Jørgensen Torben,Kamatani Yoichiro,Kandeel Fouad R.,Kasturiratne Anuradhani,Katsuya Tomohiro,Kaur Varinderpal,Kawaguchi Takahisa,Keaton Jacob M.,Kho Abel N.,Khor Chiea-Chuen,Kibriya Muhammad G.,Kim Duk-Hwan,Kohara Katsuhiko,Kriebel Jennifer,Kronenberg Florian,Kuusisto Johanna,Läll Kristi,Lange Leslie A.,Lee Myung-Shik,Lee Nanette R.,Leong Aaron,Li Liming,Li Yun,Li-Gao Ruifang,Ligthart Symen,Lindgren Cecilia M.,Linneberg Allan,Liu Ching-Ti,Liu Jianjun,Locke Adam E.,Louie Tin,Luan Jian’an,Luk Andrea O.,Luo Xi,Lv Jun,Lyssenko Valeriya,Mamakou Vasiliki,Mani K. Radha,Meitinger Thomas,Metspalu Andres,Morris Andrew D.,Nadkarni Girish N.,Nadler Jerry L.,Nalls Michael A.,Nayak Uma,Nongmaithem Suraj S.,Ntalla Ioanna,Okada Yukinori,Orozco Lorena,Patel Sanjay R.,Pereira Mark A.,Peters Annette,Pirie Fraser J.,Porneala Bianca,Prasad Gauri,Preissl Sebastian,Rasmussen-Torvik Laura J.,Reiner Alexander P.,Roden Michael,Rohde Rebecca,Roll Kathryn,Sabanayagam Charumathi,Sander Maike,Sandow Kevin,Sattar Naveed,Schönherr Sebastian,Schurmann Claudia,Shahriar Mohammad,Shi Jinxiu,Shin Dong Mun,Shriner Daniel,Smith Jennifer A.,So Wing Yee,Stančáková Alena,Stilp Adrienne M.,Strauch Konstantin,Suzuki Ken,Takahashi Atsushi,Taylor Kent D.,Thorand Barbara,Thorleifsson Gudmar,Thorsteinsdottir Unnur,Tomlinson Brian,Torres Jason M.,Tsai Fuu-Jen,Tuomilehto Jaakko,Tusie-Luna Teresa,Udler Miriam S.,Valladares-Salgado Adan,van Dam Rob M.,van Klinken Jan B.,Varma Rohit,Vujkovic Marijana,Wacher-Rodarte Niels,Wheeler Eleanor,Whitsel Eric A.,Wickremasinghe Ananda R.,van Dijk Ko Willems,Witte Daniel R.,Yajnik Chittaranjan S.,Yamamoto Ken,Yamauchi Toshimasa,Yengo Loïc,Yoon Kyungheon,Yu Canqing,Yuan Jian-Min,Yusuf Salim,Zhang Liang,Zheng Wei,Rüeger Sina^ORCID,della Briotta Parolo Pietro,Joo Yoonjung Yoonie,Hayes M. Geoffrey,Raffel Leslie J.,Igase Michiya^ORCID,Ipp Eli,Redline Susan,Cho Yoon Shin,Lind Lars,Province Michael A.^ORCID,Hanis Craig L.,Peyser Patricia A.^ORCID,Ingelsson Erik,Zonderman Alan B.^ORCID,Psaty Bruce M.,Wang Ya-Xing,Rotimi Charles N.^ORCID,Becker Diane M.,Matsuda Fumihiko,Liu Yongmei,Zeggini Eleftheria^ORCID,Yokota Mitsuhiro,Rich Stephen S.^ORCID,Kooperberg Charles^ORCID,Pankow James S.^ORCID,Engert James C.^ORCID,Chen Yii-Der Ida,Froguel Philippe^ORCID,Wilson James G.,Sheu Wayne H. H.,Kardia Sharon L. R.,Wu Jer-Yuarn,Hayes M. Geoffrey^ORCID,Ma Ronald C. W.^ORCID,Wong Tien-Yin,Groop Leif^ORCID,Mook-Kanamori Dennis O.,Chandak Giriraj R.,Collins Francis S.,Bharadwaj Dwaipayan,Paré Guillaume,Sale Michèle M.,Ahsan Habibul,Motala Ayesha A.,Shu Xiao-Ou,Park Kyong-Soo,Jukema J. Wouter,Cruz Miguel,McKean-Cowdin Roberta,Grallert Harald,Cheng Ching-Yu,Bottinger Erwin P.,Dehghan Abbas,Tai E-Shyong,Dupuis Josée,Kato Norihiro,Laakso Markku,Köttgen Anna,Koh Woon-Puay,Palmer Colin N. A.,Liu Simin,Abecasis Goncalo,Kooner Jaspal S.,Loos Ruth J. F.,North Kari E.,Haiman Christopher A.,Florez Jose C.,Saleheen Danish,Hansen Torben,Pedersen Oluf,Mägi Reedik,Langenberg Claudia,Wareham Nicholas J.,Maeda Shiro,Kadowaki Takashi,Lee Juyoung,Millwood Iona Y.,Walters Robin G.,Stefansson Kari,Myers Simon R.,Ferrer Jorge,Gaulton Kyle J.,Meigs James B.,Mohlke Karen L.,Gloyn Anna L.,Bowden Donald W.,Below Jennifer E.,Chambers John C.,Sim Xueling,Boehnke Michael,Rotter Jerome I.,McCarthy Mark I.,Morris Andrew P.^ORCID, ,

Funder

All funding listed in Supplementary Note.

Publisher

Springer Science and Business Media LLC

Subject

Genetics

Link

https://www.nature.com/articles/s41588-022-01058-3.pdf

Reference66 articles.

1. NCD Risk Factor Collaboration. Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants. Lancet 387, 1513–1530 (2016).

2. GBD 2015 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet 388, 1545–1602 (2016).

3. Voight, B. F. et al. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat. Genet. 42, 579–589 (2010).