Transposition enables low-input single-molecule concurrent genomics and epigenomics
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Publisher
Springer Science and Business Media LLC
Link
https://www.nature.com/articles/s41588-024-01753-3.pdf
Reference5 articles.
1. Chechova, M. & Miga, K. H. Comprehensive variant discovery in the era of complete human reference genomes. Nat. Methods 20, 17–19 (2023). This review article highlights recent advances in telomere-to-telomere genomics enabled by SMS.
2. Lucas, M. C. & Novoa, E. M. Long-read sequencing in the era of epigenomics and epitranscriptomics. Nat. Methods 20, 25–29 (2023). This review provides an overview of detection of modified nucleobases via SMS.
3. Abdulhay, N. J. et al. Massively multiplex single-molecule oligonucleosome footprinting. Elife 9, e59404 (2020). This article describes SAMOSA, a strategy for single-molecule chromatin profiling via exogenous adenine methylation using the non-specific m6dAse EcoGII.
4. Adey, A. et al. Rapid, low-input, low-bias construction of shotgun fragment libraries by high-density in vitro transposition. Genome Biol. 11, R119 (2010). This paper describes the application of simultaneous Tn5 transposition of sequencing adapters and input DNA fragmentation for Illumina library preparation.
5. Adey, A. Tagmentation-based single-cell genomics. Genome Res. 31, 1693–1705 (2021). This article reviews the role of tagmentation in development of low-input and single-cell short-read sequencing methods.
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