Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy-Reference-Cited by-同舟云学术

Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy

Published:2023-06-19 Issue:7 Volume:55 Page:1091-1105
ISSN:1061-4036
Container-title:Nature Genetics
language:en
Short-container-title:Nat Genet

Author:

Kiryluk Krzysztof^ORCID,Sanchez-Rodriguez Elena^ORCID,Zhou Xu-Jie,Zanoni Francesca,Liu Lili^ORCID,Mladkova Nikol,Khan Atlas^ORCID,Marasa Maddalena,Zhang Jun Y.^ORCID,Balderes Olivia,Sanna-Cherchi Simone^ORCID,Bomback Andrew S.^ORCID,Canetta Pietro A.^ORCID,Appel Gerald B.,Radhakrishnan Jai,Trimarchi Hernan,Sprangers Ben^ORCID,Cattran Daniel C.,Reich Heather,Pei York,Ravani Pietro,Galesic Kresimir,Maixnerova Dita,Tesar Vladimir^ORCID,Stengel Benedicte,Metzger Marie,Canaud Guillaume,Maillard Nicolas,Berthoux Francois,Berthelot Laureline^ORCID,Pillebout Evangeline,Monteiro Renato,Nelson Raoul,Wyatt Robert J.,Smoyer William,Mahan John,Samhar Al-Akash,Hidalgo Guillermo,Quiroga Alejandro,Weng Patricia,Sreedharan Raji,Selewski David,Davis Keefe,Kallash Mahmoud,Vasylyeva Tetyana L.^ORCID,Rheault Michelle,Chishti Aftab,Ranch Daniel^ORCID,Wenderfer Scott E.^ORCID,Samsonov Dmitry,Claes Donna J.,Akchurin Oleh^ORCID,Goumenos Dimitrios,Stangou Maria^ORCID,Nagy Judit,Kovacs Tibor,Fiaccadori Enrico,Amoroso Antonio^ORCID,Barlassina Cristina,Cusi Daniele,Del Vecchio Lucia,Battaglia Giovanni Giorgio,Bodria Monica,Boer Emanuela,Bono Luisa,Boscutti Giuliano,Caridi Gianluca^ORCID,Lugani Francesca,Ghiggeri GianMarco^ORCID,Coppo Rosanna,Peruzzi Licia^ORCID,Esposito Vittoria,Esposito Ciro,Feriozzi Sandro,Polci Rosaria,Frasca Giovanni,Galliani Marco,Garozzo Maurizio,Mitrotti Adele,Gesualdo Loreto,Granata Simona,Zaza Gianluigi^ORCID,Londrino Francesco,Magistroni Riccardo^ORCID,Pisani Isabella,Magnano Andrea,Marcantoni Carmelita,Messa Piergiorgio,Mignani Renzo,Pani Antonello,Ponticelli Claudio,Roccatello Dario^ORCID,Salvadori Maurizio,Salvi Erica,Santoro Domenico,Gembillo Guido,Savoldi Silvana,Spotti Donatella,Zamboli Pasquale,Izzi Claudia,Alberici Federico,Delbarba Elisa,Florczak Michał,Krata Natalia^ORCID,Mucha Krzysztof^ORCID,Pączek Leszek,Niemczyk Stanisław,Moszczuk Barbara,Pańczyk-Tomaszewska Malgorzata,Mizerska-Wasiak Malgorzata,Perkowska-Ptasińska Agnieszka,Bączkowska Teresa,Durlik Magdalena,Pawlaczyk Krzysztof,Sikora Przemyslaw,Zaniew Marcin,Kaminska Dorota,Krajewska Magdalena^ORCID,Kuzmiuk-Glembin Izabella^ORCID,Heleniak Zbigniew,Bullo-Piontecka Barbara,Liberek Tomasz,Dębska-Slizien Alicja,Hryszko Tomasz^ORCID,Materna-Kiryluk Anna,Miklaszewska Monika,Szczepańska Maria^ORCID,Dyga Katarzyna,Machura Edyta,Siniewicz-Luzeńczyk Katarzyna,Pawlak-Bratkowska Monika,Tkaczyk Marcin,Runowski Dariusz,Kwella Norbert,Drożdż Dorota,Habura Ireneusz^ORCID,Kronenberg Florian^ORCID,Prikhodina Larisa^ORCID,van Heel David^ORCID,Fontaine Bertrand,Cotsapas Chris,Wijmenga Cisca,Franke Andre^ORCID,Annese Vito,Gregersen Peter K.,Parameswaran Sreeja,Weirauch Matthew^ORCID,Kottyan Leah^ORCID,Harley John B.,Suzuki Hitoshi^ORCID,Narita Ichiei^ORCID,Goto Shin,Lee Hajeong,Kim Dong Ki^ORCID,Kim Yon Su,Park Jin-Ho^ORCID,Cho BeLong,Choi Murim^ORCID,Van Wijk Ans,Huerta Ana^ORCID,Ars Elisabet^ORCID,Ballarin Jose,Lundberg Sigrid^ORCID,Vogt Bruno^ORCID,Mani Laila-Yasmin^ORCID,Caliskan Yasar,Barratt Jonathan,Abeygunaratne Thilini,Kalra Philip A.,Gale Daniel P.^ORCID,Panzer Ulf,Rauen Thomas,Floege Jürgen,Schlosser Pascal^ORCID,Ekici Arif B.^ORCID,Eckardt Kai-Uwe^ORCID,Chen Nan,Xie Jingyuan,Lifton Richard P.,Loos Ruth J. F.^ORCID,Kenny Eimear E.,Ionita-Laza Iuliana^ORCID,Köttgen Anna^ORCID,Julian Bruce A.,Novak Jan^ORCID,Scolari Francesco,Zhang Hong,Gharavi Ali G.^ORCID

Funder

U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

Springer Science and Business Media LLC

Subject

Genetics

Link

https://www.nature.com/articles/s41588-023-01422-x.pdf

Reference93 articles.

1. Feehally, J. et al. HLA has strongest association with IgA nephropathy in genome-wide analysis. J. Am. Soc. Nephrol. 21, 1791–1797 (2010).

2. Gharavi, A. G. et al. Genome-wide association study identifies susceptibility loci for IgA nephropathy. Nat. Genet. 43, 321–327 (2011).

3. Kiryluk, K. et al. Geographic differences in genetic susceptibility to IgA nephropathy: GWAS replication study and geospatial risk analysis. PLoS Genet. 8, e1002765 (2012).