Complex synthetic lethality in cancer
Author:
Funder
Breast Cancer Now
Cancer Research UK
Basser Foundation
Science Foundation
Publisher
Springer Science and Business Media LLC
Subject
Genetics
Link
https://www.nature.com/articles/s41588-023-01557-x.pdf
Reference58 articles.
1. Ryan, C. J., Bajrami, I. & Lord, C. J. Synthetic lethality and cancer—penetrance as the major barrier. Trends Cancer 4, 671–683 (2018).
2. Fisher, R. A. The correlation between relatives on the supposition of Mendelian inheritance. Trans. R. Soc. Edinb. 52, 399–433 (1919).
3. Kaelin, W. G. Jr. The concept of synthetic lethality in the context of anticancer therapy. Nat. Rev. Cancer 5, 689–698 (2005).
4. Lord, C. J. & Ashworth, A. PARP inhibitors: synthetic lethality in the clinic. Science 355, 1152–1158 (2017).
5. Behan, F. M. et al. Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens. Nature 568, 511–516 (2019).
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