Single-cell genome sequencing of human neurons identifies somatic point mutation and indel enrichment in regulatory elements-Reference-Cited by-同舟云学术

Single-cell genome sequencing of human neurons identifies somatic point mutation and indel enrichment in regulatory elements

Published:2022-09-26 Issue:10 Volume:54 Page:1564-1571
ISSN:1061-4036
Container-title:Nature Genetics
language:en
Short-container-title:Nat Genet

Author:

Luquette Lovelace J.^ORCID,Miller Michael B.^ORCID,Zhou Zinan,Bohrson Craig L.,Zhao Yifan^ORCID,Jin Hu^ORCID,Gulhan Doga,Ganz Javier^ORCID,Bizzotto Sara^ORCID,Kirkham Samantha^ORCID,Hochepied Tino,Libert Claude,Galor Alon,Kim Junho^ORCID,Lodato Michael A.,Garaycoechea Juan I.,Gawad Charles^ORCID,West Jay,Walsh Christopher A.^ORCID,Park Peter J.^ORCID

Funder

U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health

U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute

U.S. Department of Health & Human Services | NIH | National Institute on Aging

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute

BrightFocus Foundation

Doris Duke Charitable Foundation

The Brigham and Women’s Hospital Program for Interdisciplinary Neuroscience through a gift from Lawrence and Tiina Rand.

PRMRP Discovery Award and the Edward R. and Anne G. Lefler Center postdoctoral fellowship.

The Allen Discovery Center program, a Paul G. Allen Frontiers Group advised program of the Paul G. Allen Family Foundation (C.A.W.). C.A.W. is an Investigator of the Howard Hughes Medical Institute.

Publisher

Springer Science and Business Media LLC

Subject

Genetics

Link

https://www.nature.com/articles/s41588-022-01180-2.pdf

Reference44 articles.

1. Poduri, A., Evrony, G. D., Cai, X. & Walsh, C. A. Somatic mutation, genomic variation, and neurological disease. Science 341, 43–51 (2013).

2. Lodato, M. et al. Somatic mutation in single human neurons tracks developmental and transcriptional history. Science 350, 94–98 (2015).

3. Martincorena, I. et al. High burden and pervasive positive selection of somatic mutations in normal human skin. Science 348, 880–886 (2015).

4. Jaiswal, S. et al. Clonal hematopoiesis and risk of atherosclerotic cardiovascular disease. N. Engl. J. Med. 377, 111–121 (2017).

5. Blokzijl, F. et al. Tissue-specific mutation accumulation in human adult stem cells during life. Nature 538, 260–264 (2016).

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