Genome-wide association analysis of venous thromboembolism identifies new risk loci and genetic overlap with arterial vascular disease
Author:
Funder
U.S. Department of Health & Human Services | National Institutes of Health
U.S. Department of Veterans Affairs
Publisher
Springer Science and Business Media LLC
Subject
Genetics
Link
http://www.nature.com/articles/s41588-019-0519-3.pdf
Reference49 articles.
1. Heit, J. A. Epidemiology of venous thromboembolism. Nat. Rev. Cardiol. 12, 464–474 (2015).
2. Bertina, R. M. et al. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 369, 64–67 (1994).
3. Poort, S. R., Rosendaal, F. R., Reitsma, P. H. & Bertina, R. M. A common genetic variation in the 3′-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 88, 3698–3703 (1996).
4. Klarin, D., Emdin, C. A., Natarajan, P., Conrad, M. F. & Kathiresan, S. Genetic analysis of venous thromboembolism in UK biobank identifies the ZFPM2 locus and implicates obesity as a causal risk factor. Circ. Cardiovasc. Genet. 10, e001643 (2017).
5. Hinds, D. A. et al. Genome-wide association analysis of self-reported events in 6135 individuals and 252 827 controls identifies 8 loci associated with thrombosis. Hum. Mol. Genet. 25, 1867–1874 (2016).
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