Genome-wide association analysis of venous thromboembolism identifies new risk loci and genetic overlap with arterial vascular disease
-
Published:2019-11
Issue:11
Volume:51
Page:1574-1579
-
ISSN:1061-4036
-
Container-title:Nature Genetics
-
language:en
-
Short-container-title:Nat Genet
Author:
Klarin DerekORCID, , Busenkell Emma, Judy Renae, Lynch JulieORCID, Levin MichaelORCID, Haessler Jeffery, Aragam Krishna, Chaffin MarkORCID, Haas Mary, Lindström Sara, Assimes Themistocles L.ORCID, Huang Jie, Min Lee KyungORCID, Shao Qing, Huffman Jennifer E.ORCID, Kabrhel Christopher, Huang Yunfeng, Sun Yan V., Vujkovic MarijanaORCID, Saleheen Danish, Miller Donald R., Reaven Peter, DuVall Scott, Boden William E., Pyarajan Saiju, Reiner Alex P., Trégouët David-Alexandre, Henke Peter, Kooperberg Charles, Gaziano J. Michael, Concato John, Rader Daniel J., Cho Kelly, Chang Kyong-Mi, Wilson Peter W. F., Smith Nicholas L., O’Donnell Christopher J., Tsao Philip S.ORCID, Kathiresan SekarORCID, Obi Andrea, Damrauer Scott M.ORCID, Natarajan PradeepORCID,
Funder
U.S. Department of Health & Human Services | National Institutes of Health U.S. Department of Veterans Affairs
Publisher
Springer Science and Business Media LLC
Reference49 articles.
1. Heit, J. A. Epidemiology of venous thromboembolism. Nat. Rev. Cardiol. 12, 464–474 (2015). 2. Bertina, R. M. et al. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 369, 64–67 (1994). 3. Poort, S. R., Rosendaal, F. R., Reitsma, P. H. & Bertina, R. M. A common genetic variation in the 3′-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 88, 3698–3703 (1996). 4. Klarin, D., Emdin, C. A., Natarajan, P., Conrad, M. F. & Kathiresan, S. Genetic analysis of venous thromboembolism in UK biobank identifies the ZFPM2 locus and implicates obesity as a causal risk factor. Circ. Cardiovasc. Genet. 10, e001643 (2017). 5. Hinds, D. A. et al. Genome-wide association analysis of self-reported events in 6135 individuals and 252 827 controls identifies 8 loci associated with thrombosis. Hum. Mol. Genet. 25, 1867–1874 (2016).
Cited by
172 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
|
|