Loss of ZnT8 function protects against diabetes by enhanced insulin secretion
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Published:2019-11
Issue:11
Volume:51
Page:1596-1606
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ISSN:1061-4036
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Container-title:Nature Genetics
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language:en
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Short-container-title:Nat Genet
Author:
Dwivedi Om PrakashORCID, Lehtovirta Mikko, Hastoy BenoitORCID, Chandra VikashORCID, Krentz Nicole A. J.ORCID, Kleiner Sandra, Jain Deepak, Richard Ann-Marie, Abaitua Fernando, Beer Nicola L., Grotz AntjeORCID, Prasad Rashmi B.ORCID, Hansson OlaORCID, Ahlqvist EmmaORCID, Krus Ulrika, Artner IsabellaORCID, Suoranta Anu, Gomez Daniel, Baras ArisORCID, Champon Benoite, Payne Anthony J., Moralli DanielaORCID, Thomsen Soren K., Kramer Philipp, Spiliotis IoannisORCID, Ramracheya Reshma, Chabosseau Pauline, Theodoulou Andria, Cheung Rebecca, van de Bunt Martijn, Flannick Jason, Trombetta Maddalena, Bonora Enzo, Wolheim Claes B., Sarelin Leena, Bonadonna Riccardo C., Rorsman PatrikORCID, Davies BenjaminORCID, Brosnan Julia, McCarthy Mark I.ORCID, Otonkoski TimoORCID, Lagerstedt Jens O., Rutter Guy A.ORCID, Gromada Jesper, Gloyn Anna L.ORCID, Tuomi TiinamaijaORCID, Groop LeifORCID
Funder
Academy of Finland Vetenskapsrådet RCUK | Medical Research Council Wellcome Trust Diabetes UK
Publisher
Springer Science and Business Media LLC
Reference59 articles.
1. Chabosseau, P. & Rutter, G. A. Zinc and diabetes. Arch. Biochem. Biophys. 611, 79–85 (2016). 2. Chimienti, F., Devergnas, S., Favier, A. & Seve, M. Identification and cloning of a β-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules. Diabetes 53, 2330–2337 (2004). 3. Flannick, J. et al. Loss-of-function mutations in SLC30A8 protect against type 2 diabetes. Nat. Genet. 46, 357–363 (2014). 4. Parsons, D. S., Hogstrand, C. & Maret, W. The C-terminal cytosolic domain of the human zinc transporter ZnT8 and its diabetes risk variant. FEBS J. 285, 1237–1250 (2018). 5. Sladek, R. et al. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 445, 881–885 (2007).
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