A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response
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Published:2021-10
Issue:10
Volume:53
Page:1504-1516
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ISSN:1061-4036
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Container-title:Nature Genetics
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language:en
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Short-container-title:Nat Genet
Author:
Luo YangORCID, Kanai MasahiroORCID, Choi Wanson, Li Xinyi, Sakaue SaoriORCID, Yamamoto Kenichi, Ogawa Kotaro, Gutierrez-Arcelus MariaORCID, Gregersen Peter K.ORCID, Stuart Philip E.ORCID, Elder James T.ORCID, Forer LukasORCID, Schönherr Sebastian, Fuchsberger ChristianORCID, Smith Albert V.ORCID, Fellay JacquesORCID, Carrington MaryORCID, Haas David W., Guo Xiuqing, Palmer Nicholette D.ORCID, Chen Yii-Der Ida, Rotter Jerome I.ORCID, Taylor Kent D.ORCID, Rich Stephen S.ORCID, Correa AdolfoORCID, Wilson James G., Kathiresan Sekar, Cho Michael H.ORCID, Metspalu AndresORCID, Esko TonuORCID, Okada YukinoriORCID, Han BuhmORCID, Abe Namiko, Abecasis Gonçalo, Aguet Francois, Albert Christine, Almasy Laura, Alonso Alvaro, Ament Seth, Anderson Peter, Anugu Pramod, Applebaum-Bowden Deborah, Ardlie Kristin, Dan Arking , Arnett Donna K., Ashley-Koch Allison, Aslibekyan Stella, Assimes Tim, Auer Paul, Avramopoulos Dimitrios, Ayas Najib, Balasubramanian Adithya, Barnard John, Barnes Kathleen, Barr R. Graham, Barron-Casella Emily, Barwick Lucas, Beaty Terri, Beck Gerald, Becker Diane, Becker Lewis, Beer Rebecca, Beitelshees Amber, Benjamin Emelia, Benos Takis, Bezerra Marcos, Bielak Larry, Bis Joshua, Blackwell Thomas, Blangero John, Boerwinkle Eric, Bowden Donald W., Bowler Russell, Brody Jennifer, Broeckel Ulrich, Broome Jai, Brown Deborah, Bunting Karen, Burchard Esteban, Bustamante Carlos, Buth Erin, Cade Brian, Cardwell Jonathan, Carey Vincent, Carrier Julie, Carty Cara, Casaburi Richard, Romero Juan P. Casas, Casella James, Castaldi Peter, Chaffin Mark, Chang Christy, Chang Yi-Cheng, Chasman Daniel, Chavan Sameer, Chen Bo-Juen, Chen Wei-Min, Choi Seung Hoan, Chuang Lee-Ming, Chung Mina, Chung Ren-Hua, Clish Clary, Comhair Suzy, Conomos Matthew, Cornell Elaine, Crandall Carolyn, Crapo James, Cupples L. Adrienne, Curran Joanne, Curtis Jeffrey, Custer Brian, Damcott Coleen, Darbar Dawood, David Sean, Davis Colleen, Daya Michelle, de Andrade Mariza, Fuentes Lisa de las, de Vries Paul, DeBaun Michael, Deka Ranjan, DeMeo Dawn, Devine Scott, Dinh Huyen, Doddapaneni Harsha, Duan Qing, Dugan-Perez Shannon, Duggirala Ravi, Durda Jon Peter, Dutcher Susan K., Eaton Charles, Ekunwe Lynette, Boueiz Adel El, Ellinor Patrick, Emery Leslie, Erzurum Serpil, Farber Charles, Farek Jesse, Fingerlin Tasha, Flickinger Matthew, Fornage Myriam, Franceschini Nora, Frazar Chris, Fu Mao, Fullerton Stephanie M., Fulton Lucinda, Gabriel Stacey, Gan Weiniu, Gao Shanshan, Gao Yan, Gass Margery, Geiger Heather, Gelb Bruce, Geraci Mark, Germer Soren, Gerszten Robert, Ghosh Auyon, Gibbs Richard, Gignoux Chris, Gladwin Mark, Glahn David, Gogarten Stephanie, Gong Da-Wei, Goring Harald, Graw Sharon, Gray Kathryn J., Grine Daniel, Gross Colin, Gu C. Charles, Guan Yue, Gupta Namrata, Haas David M., Haessler Jeff, Hall Michael, Han Yi, Hanly Patrick, Harris Daniel, Hawley Nicola L., He Jiang, Heavner Ben, Heckbert Susan, Hernandez Ryan, Herrington David, Hersh Craig, Hidalgo Bertha, Hixson James, Hobbs Brian, Hokanson John, Hong Elliott, Hoth Karin, Hsiung Chao, Hu Jianhong, Hung Yi-Jen, Huston Haley, Hwu Chii Min, Irvin Marguerite Ryan, Jackson Rebecca, Jain Deepti, Jaquish Cashell, Johnsen Jill, Johnson Andrew, Johnson Craig, Johnston Rich, Jones Kimberly, Kang Hyun Min, Kaplan Robert, Kardia Sharon, Kelly Shannon, Kenny Eimear, Kessler Michael, Khan Alyna, Khan Ziad, Kim Wonji, Kimoff John, Kinney Greg, Konkle Barbara, Kooperberg Charles, Kramer Holly, Lange Christoph, Lange Ethan, Lange Leslie, Laurie Cathy, Laurie Cecelia, LeBoff Meryl, Lee Jiwon, Lee Sandra, Lee Wen-Jane, LeFaive Jonathon, Levine David, Dan Levy , Lewis Joshua, Li Xiaohui, Li Yun, Lin Henry, Lin Honghuang, Lin Xihong, Liu Simin, Liu Yongmei, Liu Yu, Loos Ruth J. F., Lubitz Steven, Lunetta Kathryn, Luo James, Magalang Ulysses, Mahaney Michael, Make Barry, Manichaikul Ani, Manning Alisa, Manson JoAnn, Martin Lisa, Marton Melissa, Mathai Susan, Mathias Rasika, May Susanne, McArdle Patrick, McDonald Merry-Lynn, McFarland Sean, McGarvey Stephen, McGoldrick Daniel, McHugh Caitlin, McNeil Becky, Mei Hao, Meigs James, Menon Vipin, Mestroni Luisa, Metcalf Ginger, Meyers Deborah A., Mignot Emmanuel, Mikulla Julie, Min Nancy, Minear Mollie, Minster Ryan L., Mitchell Braxton D., Moll Matt, Momin Zeineen, Montasser May E., Montgomery Courtney, Muzny Donna, Mychaleckyj Josyf C., Nadkarni Girish, Naik Rakhi, Naseri Take, Natarajan Pradeep, Nekhai Sergei, Nelson Sarah C., Neltner Bonnie, Nessner Caitlin, Nickerson Deborah, Nkechinyere Osuji, North Kari, O’Connell Jeff, O’Connor Tim, Ochs-Balcom Heather, Okwuonu Geoffrey, Pack Allan, Paik David T., Pankow James, Papanicolaou George, Parker Cora, Peloso Gina, Peralta Juan Manuel, Perez Marco, Perry James, Peters Ulrike, Peyser Patricia, Phillips Lawrence S., Pleiness Jacob, Pollin Toni, Post Wendy, Becker Julia Powers, Boorgula Meher Preethi, Preuss Michael, Psaty Bruce, Qasba Pankaj, Qiao Dandi, Qin Zhaohui, Rafaels Nicholas, Raffield Laura, Rajendran Mahitha, Ramachandran Vasan S., Rao D. C., Rasmussen-Torvik Laura, Ratan Aakrosh, Redline Susan, Reed Robert, Reeves Catherine, Regan Elizabeth, Reiner Alex, Reupena Muagututi’a Sefuiva, Rice Ken, Robillard Rebecca, Robine Nicolas, Dan Roden , Roselli Carolina, Ruczinski Ingo, Runnels Alexi, Russell Pamela, Ruuska Sarah, Ryan Kathleen, Sabino Ester Cerdeira, Saleheen Danish, Salimi Shabnam, Salvi Sejal, Salzberg Steven, Sandow Kevin, Sankaran Vijay G., Santibanez Jireh, Schwander Karen, Schwartz David, Sciurba Frank, Seidman Christine, Seidman Jonathan, Sériès Frédéric, Sheehan Vivien, Sherman Stephanie L., Shetty Amol, Shetty Aniket, Sheu Wayne Hui-Heng, Shoemaker M. Benjamin, Silver Brian, Silverman Edwin, Skomro Robert, Smith Jennifer, Smith Josh, Smith Nicholas, Smith Tanja, Smoller Sylvia, Snively Beverly, Snyder Michael, Sofer Tamar, Sotoodehnia Nona, Stilp Adrienne M., Storm Garrett, Streeten Elizabeth, Su Jessica Lasky, Sung Yun Ju, Sylvia Jody, Szpiro Adam, Taliun Daniel, Tang Hua, Taub Margaret, Taylor Matthew, Taylor Simeon, Telen Marilyn, Thornton Timothy A., Threlkeld Machiko, Tinker Lesley, Tirschwell David, Tishkoff Sarah, Tiwari Hemant, Tong Catherine, Tracy Russell, Tsai Michael, Vaidya Dhananjay, Van Den Berg David, VandeHaar Peter, Vrieze Scott, Walker Tarik, Wallace Robert, Walts Avram, Wang Fei Fei, Wang Heming, Wang Jiongming, Watson Karol, Watt Jennifer, Weeks Daniel E., Weinstock Joshua, Weir Bruce, Weiss Scott T., Weng Lu-Chen, Wessel Jennifer, Willer Cristen, Williams Kayleen, Williams L. Keoki, Wilson Carla, Wilson James, Winterkorn Lara, Wong Quenna, Wu Joseph, Xu Huichun, Yanek Lisa, Yang Ivana, Yu Ketian, Zekavat Seyedeh Maryam, Zhang Yingze, Zhao Snow Xueyan, Zhao Wei, Zhu Xiaofeng, Zody Michael, Zoellner Sebastian, McLaren Paul J.ORCID, Raychaudhuri SoumyaORCID,
Funder
U.S. Department of Health & Human Services | National Institutes of Health U.S. Department of Health & Human Services | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases Wake Forest University American Diabetes Association
Publisher
Springer Science and Business Media LLC
Reference76 articles.
1. International HIV Controllers Study et al. The major genetic determinants of HIV-1 control affect HLA class I peptide presentation. Science 330, 1551–1557 (2010). 2. Raychaudhuri, S. et al. Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis. Nat. Genet. 44, 291–296 (2012). 3. Evans, D. M. et al. Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. Nat. Genet. 43, 761–767 (2011). 4. Snyder, A. et al. Genetic basis for clinical response to CTLA-4 blockade in melanoma. N. Engl. J. Med. 371, 2189–2199 (2014). 5. Buniello, A. et al. The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019. Nucleic Acids Res. 47, D1005–D1012 (2019).
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