Structural insights into ligand recognition and activation of the melanocortin-4 receptor-Reference-Cited by-同舟云学术

Structural insights into ligand recognition and activation of the melanocortin-4 receptor

Published:2021-08-25 Issue:11 Volume:31 Page:1163-1175
ISSN:1001-0602
Container-title:Cell Research
language:en
Short-container-title:Cell Res

Author:

Zhang Huibing,Chen Li-Nan,Yang Dehua^ORCID,Mao Chunyou^ORCID,Shen Qingya^ORCID,Feng Wenbo,Shen Dan-Dan^ORCID,Dai Antao,Xie Shanshan^ORCID,Zhou Yan,Qin Jiao,Sun Jin-Peng,Scharf Daniel H.,Hou Tingjun,Zhou Tianhua,Wang Ming-Wei^ORCID,Zhang Yan^ORCID

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Molecular Biology

Link

https://www.nature.com/articles/s41422-021-00552-3.pdf

Reference71 articles.

1. Krashes, M. J., Lowell, B. B. & Garfield, A. S. Melanocortin-4 receptor-regulated energy homeostasis. Nat. Neurosci. 19, 206–219 (2016).

2. Tao, Y. X. The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology. Endocr. Rev. 31, 506–543 (2010).

3. Kuhnen, P., Krude, H. & Biebermann, H. Melanocortin-4 receptor signalling: importance for weight regulation and obesity treatment. Trends Mol. Med. 25, 136–148 (2019).

4. Siljee, J. E. et al. Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity. Nat. Genet. 50, 180–185 (2018).

5. Hinney, A., Volckmar, A. L. & Knoll, N. Melanocortin-4 receptor in energy homeostasis and obesity pathogenesis. Prog. Mol. Biol. Transl. Sci. 114, 147–191 (2013).

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