Binding pathway determines norepinephrine selectivity for the human β1AR over β2AR-Reference-Cited by-同舟云学术

Binding pathway determines norepinephrine selectivity for the human β1AR over β2AR

Published:2020-10-22 Issue:5 Volume:31 Page:569-579
ISSN:1001-0602
Container-title:Cell Research
language:en
Short-container-title:Cell Res

Author:

Xu Xinyu^ORCID,Kaindl Jonas^ORCID,Clark Mary J.,Hübner Harald,Hirata Kunio^ORCID,Sunahara Roger K.,Gmeiner Peter^ORCID,Kobilka Brian K.,Liu Xiangyu^ORCID

Funder

the Beijing Advanced Innovation Center for Structural Biology, Tsinghua University

the DFG grant GRK 1910

U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Molecular Biology

Link

https://www.nature.com/articles/s41422-020-00424-2.pdf

Reference69 articles.

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3. Rybin, V. O., Xu, X., Lisanti, M. P. & Steinberg, S. F. Differential targeting of beta -adrenergic receptor subtypes and adenylyl cyclase to cardiomyocyte caveolae. A mechanism to functionally regulate the cAMP signaling pathway. J. Biol. Chem. 275, 41447–41457 (2000).

4. Xiang, Y., Devic, E. & Kobilka, B. The PDZ binding motif of the beta 1 adrenergic receptor modulates receptor trafficking and signaling in cardiac myocytes. J. Biol. Chem. 277, 33783–33790 (2002).

5. Xiang, Y. & Kobilka, B. The PDZ-binding motif of the beta2-adrenoceptor is essential for physiologic signaling and trafficking in cardiac myocytes. Proc. Natl. Acad. Sci. USA 100, 10776–10781 (2003).

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