Semagacestat's fall: where next for AD therapies?
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Biochemistry, Genetics and Molecular Biology,General Medicine
Link
http://www.nature.com/articles/nm.3365.pdf
Reference16 articles.
1. Doody, R.S. et al. A phase 3 trial of semagacestat for treatment of Alzheimer's disease. N. Engl. J. Med. 369, 341–350 (2013).
2. Fleisher, A.S. et al. Phase 2 safety trial targeting amyloid b production with a γ-secretase inhibitor in Alzheimer disease. Arch. Neurol. 65, 1031–1038 (2008).
3. Portelius, E. et al. A novel Aβ isoform pattern in CSF reflects γ-secretase inhibition in Alzheimer's disease. Alzheimers Res. Ther. 2, 7 (2010).
4. Scheuner, D. et al. Secreted amyloid b-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat. Med. 2, 864–870 (1996).
5. Blennow, K., Hampel, H., Weiner, M. & Zetterberg, H. Cerebrospinal fluid and plasma biomarkers in Alzheimer disease. Nat. Rev. Neurol. 6, 131–144 (2010).
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