Extra-helical binding site of a glucagon receptor antagonist-Reference-Cited by-同舟云学术

Extra-helical binding site of a glucagon receptor antagonist

Published:2016-04-25 Issue:7602 Volume:533 Page:274-277
ISSN:0028-0836
Container-title:Nature
language:en
Short-container-title:Nature

Author:

Jazayeri Ali,Doré Andrew S.,Lamb Daniel,Krishnamurthy Harini,Southall Stacey M.,Baig Asma H.,Bortolato Andrea,Koglin Markus,Robertson Nathan J.,Errey James C.,Andrews Stephen P.,Teobald Iryna,Brown Alastair J. H.,Cooke Robert M.,Weir Malcolm,Marshall Fiona H.

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/nature17414.pdf

Reference14 articles.

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2. Bagger, J. I., Knop, F. K., Holst, J. J. & Vilsbøll, T. Glucagon antagonism as a potential therapeutic target in type 2 diabetes. Diabetes Obes. Metab. 13, 965–971 (2011)

3. Siu, F. Y et al. Structure of the human glucagon class B G-protein-coupled receptor. Nature 499, 444–449 (2013)

4. Xiong, Y. et al. Discovery of a novel glucagon receptor antagonist N-[(4-(1S)-1-[3-(3, 5-dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)-1H-pyrazol-1-yl]ethylphenyl)carbonyl]-β-alanine (MK-0893) for the treatment of type II diabetes. J. Med. Chem. 55, 6137–6148 (2012)

5. Hollenstein, K. et al. Structure of class B GPCR corticotropin-releasing factor receptor 1. Nature 499, 438–443 (2013)

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