The cardiovascular and pharmacokinetic profile of dofetilide in conscious telemetered beagle dogs and cynomolgus monkeys

Author:

Haushalter T M,Friedrichs G S,Reynolds D L,Barecki-Roach M,Pastino G,Hayes R,Bass A S

Publisher

Wiley

Subject

Pharmacology

Reference27 articles.

1. Effect of cimedtidine and ranitidine on pharmacokinetics and pharmacodynamics of a single dose of dofetilide;Abel;Br J Clin Pharmacol,2000

2. The pharmacokinetics and pharmacodynamics of oral dofetilide after twice daily and three times daily dosing;Allen;Br J Clin Pharmacol,2000

3. Anon 2001 ICH S7A Safety pharmacology studies for human pharmaceuticals, implemented by MHLW, CPMP, FDA Federal Register 66 36791 36792

4. Anon 2005 ICHS7B Guidance on safety pharmacology studies for assessing the potential for delayed ventricular repolarization (QT interval prolongation) by human pharmaceuticals http://www.fda.gov/cder/guidance/index.htm

5. Assessing predictors of drug-induced torsade de pointes;Belardinelli;Trends Pharmacol Sci,2003

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