Novel small molecules disrupting Hec1/Nek2 interaction ablate tumor progression by triggering Nek2 degradation through a death-trap mechanism
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Genetics,Molecular Biology
Link
http://www.nature.com/articles/onc201467.pdf
Reference48 articles.
1. Foley EA, Kapoor TM . Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore. Nat Rev Mol Cell Biol 2013; 14: 25–37.
2. Walczak CE, Cai S, Khodjakov A . Mechanisms of chromosome behaviour during mitosis. Nat Rev Mol Cell Biol 2010; 11: 91–102.
3. Rath O, Kozielski F . Kinesins and cancer. Nat Rev Cancer 2012; 12: 527–539.
4. Chan KS, Koh CG, Li HY . Mitosis-targeted anti-cancer therapies: where they stand. Cell Death Dis 2012; 3: e411.
5. Jordan M, Wilson L . Microtubules as a target for anticancer drugs. Nat Rev Cancer 2006; 4: 253–265.
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