Adoptively transferred donor IL-17-producing CD4+ T cells augment, but IL-17 alleviates, acute graft-versus-host disease

Author:

Cai Yifeng,Ma Shoubao,Liu Yuejun,Gong Huanle,Cheng Qiao,Hu Bo,Wu Yan,Yu Xiao,Dong Chen,Sun Kai,Wu Depei,Liu Haiyan

Publisher

Springer Science and Business Media LLC

Subject

Infectious Diseases,Immunology,Immunology and Allergy

Reference39 articles.

1. Coghill JM, Sarantopoulos S, Moran TP, Murphy WJ, Blazar BR, Serody JS . Effector CD4+ T cells, the cytokines they generate, and GVHD: something old and something new. Blood 2011; 117: 3268–3276.

2. Teshima T . [Pathogenesis and treatment of graft-versus-host disease]. Nihon Rinsho 2012; 70 (Suppl 2): 264–268.

3. Szebeni J, Wang MG, Pearson DA, Szot GL, Sykes M . IL-2 inhibits early increases in serum gamma interferon levels associated with graft-versus-host-disease. Transplantation 1994; 58: 1385–1393.

4. Mowat AM . Antibodies to IFN-gamma prevent immunologically mediated intestinal damage in murine graft-versus-host reaction. Immunology 1989; 68: 18–23.

5. Murphy WJ, Welniak LA, Taub DD, Wiltrout RH, Taylor PA, Vallera DA et al. Differential effects of the absence of interferon-gamma and IL-4 in acute graft-versus-host disease after allogeneic bone marrow transplantation in mice. J Clin Invest 1998; 102: 1742–1748.

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