Predicting the mutations generated by repair of Cas9-induced double-strand breaks
Author:
Publisher
Springer Science and Business Media LLC
Subject
Biomedical Engineering,Molecular Medicine,Applied Microbiology and Biotechnology,Bioengineering,Biotechnology
Link
http://www.nature.com/articles/nbt.4317.pdf
Reference49 articles.
1. Doudna, J.A. & Charpentier, E. The new frontier of genome engineering with CRISPR-Cas9. Science 346, 1258096 (2014).
2. Chiruvella, K.K., Liang, Z. & Wilson, T.E. Repair of double-strand breaks by end joining. Cold Spring Harb. Perspect. Biol. 5, a012757 (2013).
3. Her, J. & Bunting, S.F. How cells ensure correct repair of DNA double-strand breaks. J. Biol. Chem. 293, 10502–10511 (2018).
4. Truong, L.N. et al. Microhomology-mediated end joining and homologous recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells. Proc. Natl. Acad. Sci. USA 110, 7720–7725 (2013).
5. Shibata, A. Regulation of repair pathway choice at two-ended DNA double-strand breaks. Mutat. Res. 803-805, 51–55 (2017).
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