Mechanisms underlying the long-term and withdrawal effects of denosumab therapy on bone
Author:
Publisher
Springer Science and Business Media LLC
Subject
Rheumatology
Link
https://www.nature.com/articles/s41584-023-00935-3.pdf
Reference54 articles.
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2. Baron, R., Ferrari, S. & Russell, R. G. Denosumab and bisphosphonates: different mechanisms of action and effects. Bone 48, 677–692 (2011).
3. Bone, H. G. et al. 10 years of denosumab treatment in postmenopausal women with osteoporosis: results from the phase 3 randomised FREEDOM trial and open-label extension. Lancet Diabetes Endocrinol. 5, 513–523 (2017).
4. Black, D. M. et al. Treatment-related changes in bone mineral density as a surrogate biomarker for fracture risk reduction: meta-regression analyses of individual patient data from multiple randomised controlled trials. Lancet Diabetes Endocrinol. 8, 672–682 (2020).
5. Ferrari, S. et al. Further nonvertebral fracture reduction beyond 3 years for up to 10 years of denosumab treatment. J. Clin. Endocrinol. Metab. 104, 3450–3461 (2019).
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