Can molecular dynamics facilitate the design of protein–protein-interaction inhibitors?
Author:
Publisher
Springer Science and Business Media LLC
Subject
Rheumatology
Link
https://www.nature.com/articles/s41584-022-00877-2.pdf
Reference10 articles.
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3. Lu, H. et al. Recent advances in the development of protein-protein interactions modulators: mechanisms and clinical trials. Signal Transduct. Target. Ther. 5, 213 (2020).
4. Huang, D. et al. Identification of a binding site on soluble RANKL that can be targeted to inhibit soluble RANK-RANKL interactions and treat osteoporosis. Nat. Commun. 13, 5338 (2022).
5. Philippe, G. J. B., Craik, D. J. & Henriques, S. T. Converting peptides into drugs targeting intracellular protein-protein interactions. Drug Discov. Today 26, 1521–1531 (2021).
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