Characterization of the biosynthetic gene cluster (ata) for the A201A aminonucleoside antibiotic from Saccharothrix mutabilis subsp. capreolus

Author:

Saugar Irene,Molloy Brian,Sanz Eloisa,Blanca Sánchez María,Fernández-Lobato María,Jiménez Antonio

Publisher

Springer Science and Business Media LLC

Subject

Drug Discovery,Pharmacology

Reference50 articles.

1. Nie, S., Li, W. & Yu, B. Total synthesis of nucleotide antibiotic A201A. J. Am. Chem. Soc. 136, 4157–4160 (2014).

2. Hamill, R. L. & Hoehn, M. M. Antibiotics A201A and A201B and process for the production thereof. US Patent, Eli Lilly & Co. 3,843,784. Oct. 23.

3. Zhu, Q. et al. Discovery and engineered overproduction of antimicrobial nucleoside antibiotic A201A from the deep-sea marine actinomycete Marinactinospora thermotolerans SCSIO 00652. Antimicrob. Agents Chemother. 56, 110–114 (2012).

4. Ensminger, P. V. & Wright, W. E. A201A, a new antibiotic produced by Streptomyces capreolus. II. Biological studies. Abst.16th Intersci. Conference Antiomicrob. Agents Chemother. 63 (1976).

5. Kirst, H. A. et al. The structure of A201A, a novel nucleoside antibiotic. J. Antibiot. (Tokyo) 38, 575–586 (1985).

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