Harnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein-Reference-Cited by-同舟云学术

Harnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein

Published:2010-02-28 Issue:3 Volume:28 Page:256-263
ISSN:1087-0156
Container-title:Nature Biotechnology
language:en
Short-container-title:Nat Biotechnol

Author:

Bauer Peter O,Goswami Anand,Wong Hon Kit,Okuno Misako,Kurosawa Masaru,Yamada Mizuki,Miyazaki Haruko,Matsumoto Gen,Kino Yoshihiro,Nagai Yoshitaka,Nukina Nobuyuki

Publisher

Springer Science and Business Media LLC

Subject

Biomedical Engineering,Molecular Medicine,Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Link

http://www.nature.com/articles/nbt.1608.pdf

Reference61 articles.

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2. DiFiglia, M. et al. Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain. Science 277, 1990–1993 (1997).

3. Davies, S.W. et al. Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation. Cell 90, 537–548 (1997).

4. Perutz, M.F., Pope, B.J., Owen, D., Wanker, E.E. & Scherzinger, E. Aggregation of proteins with expanded glutamine and alanine repeats of the glutamine-rich and asparagine-rich domains of Sup35 and of the amyloid beta-peptide of amyloid plaques. Proc. Natl. Acad. Sci. USA 99, 5596–5600 (2002).

5. Tanaka, M. et al. Expansion of polyglutamine induces the formation of quasi-aggregate in the early stage of protein fibrillization. J. Biol. Chem. 278, 34717–34724 (2003).

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