NPM-ALK mediates phosphorylation of MSH2 at tyrosine 238, creating a functional deficiency in MSH2 and the loss of mismatch repair
Author:
Publisher
Springer Science and Business Media LLC
Subject
Oncology,Hematology
Link
http://www.nature.com/articles/bcj201535.pdf
Reference55 articles.
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2. Morris SW, Kirstein MN, Valentine MB, Dittmer KG, Shapiro DN, Saltman DL et al. Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma. Science 1994; 263: 1281–1284.
3. Pearson JD, Lee JK, Bacani JT, Lai R, Ingham RJ . NPM-ALK: the prototypic member of a family of oncogenic fusion tyrosine kinases. J Signal Transduct 2012; 2012: 123253.
4. Young LC, Bone KM, Wang P, Wu F, Adam BA, Hegazy S et al. Fusion tyrosine kinase NPM-ALK deregulates MSH2 and suppresses DNA mismatch repair function: novel insights into a potent oncoprotein. Am J Pathol 2011; 179: 411–421.
5. Li GM . Mechanisms and functions of DNA mismatch repair. Cell Res 2008; 18: 85–98.
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