Does day 11 omission of methotrexate due to toxicity influence the outcome in myeloablative hematopoietic cell transplant? Results from a single-center retrospective cohort study

Author:

Hamilton B K,Rybicki L,Haddad H,Abounader D,Yurch M,Majhail N S,Hanna R,Sobecks R,Dean R,Liu H,Hill B,Copelan E,Bolwell B,Kalaycio M

Publisher

Springer Science and Business Media LLC

Subject

Oncology,Hematology

Reference15 articles.

1. Storb R, Deeg HJ, Whitehead J, Appelbaum F, Beatty P, Bensinger W et al. Methotrexate and cyclosporine compared with cyclosporine alone for prophylaxis of acute graft versus host disease after marrow transplantation for leukemia. N Engl J Med 1986; 314: 729–735.

2. Cutler C, Li S, Kim HT, Laglenne P, Szeto KC, Hoffmeister L et al. Mucositis after allogeneic hematopoietic stem cell transplantation: a cohort study of methotrexate- and non-methotrexate-containing graft-versus-host disease prophylaxis regimens. Biol Blood Marrow Transplant 2005; 11: 383–388.

3. Deeg HJ, Spitzer TR, Cottler-Fox M, Cahill R, Pickle LW . Conditioning-related toxicity and acute graft-versus-host disease in patients given methotrexate/cyclosporine prophylaxis. Bone Marrow Transplant 1991; 7: 193–198.

4. Atkinson K, Downs K . Omission of day 11 methotrexate does not appear to influence the incidence of moderate to severe acute graft-versus-host disease, chronic graft-versus-host disease, relapse rate or survival after HLA-identical sibling bone marrow transplantation. Bone Marrow Transplant 1995; 16: 755–758.

5. Honda A, Kakihana K, Aoki J, Kobayashi T, Doki N, Sakamaki H et al. Omission of day-11 MTX, in combination with tacrolimus, is not associated with increased risk of acute graft-versus-host disease after allo-BMT. Bone Marrow Transplant 2013; 48: 307–309.

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