Accelerating ionizable lipid discovery for mRNA delivery using machine learning and combinatorial chemistry-Reference-Cited by-同舟云学术

Accelerating ionizable lipid discovery for mRNA delivery using machine learning and combinatorial chemistry

Published:2024-05-13 Issue:7 Volume:23 Page:1002-1008
ISSN:1476-1122
Container-title:Nature Materials
language:en
Short-container-title:Nat. Mater.

Author:

Li Bowen^ORCID,Raji Idris O.^ORCID,Gordon Akiva G. R.^ORCID,Sun Lizhuang,Raimondo Theresa M.^ORCID,Oladimeji Favour A.,Jiang Allen Y.^ORCID,Varley Andrew^ORCID,Langer Robert S.^ORCID,Anderson Daniel G.^ORCID

Publisher

Springer Science and Business Media LLC

Link

https://www.nature.com/articles/s41563-024-01867-3.pdf

Reference33 articles.

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3. Trepotec, Z., Lichtenegger, E., Plank, C., Aneja, M. K. & Rudolph, C. Delivery of mRNA therapeutics for the treatment of hepatic diseases. Mol. Ther. 27, 794–802 (2019).

4. Blanchard, E. L. et al. Treatment of influenza and SARS-CoV-2 infections via mRNA-encoded Cas13a in rodents. Nat. Biotechnol. 39, 717–726 (2021).

5. Qiu, M. et al. Lipid nanoparticle-mediated codelivery of Cas9 mRNA and single-guide RNA achieves liver-specific in vivo genome editing of Angptl3. Proc. Natl Acad. Sci. USA 118, e2020401118 (2021).

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