Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/43448.pdf
Reference15 articles.
1. Seip,M. & Trygstad,O. Generalized lipodystrophy, congenital and acquired (lipoatrophy). Acta Paediatr. Suppl. 413, 2–28 (1996).
2. Shimomura,I. et al. Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy. Genes Dev. 12, 3182–3194 (1998).
3. Friedman,J. M. & Halaas,J. L. Leptin and the regulation of body weight in mammals. Nature 395, 763–770 (1998).
4. Tontonoz,P., Kim,J. B., Graves,R. A. & Spiegelman,B. M. ADD1: a novel helix–loop–helix transcription factor associated with adipocyte determination and differentiation. Mol. Cell. Biol. 13, 4753–4759 (1993).
5. Brown,M. S. & Goldstein,J. L. The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 89, 331–340 (1997).
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