The uptake mechanism of PEGylated DNA polyplexes by the liver influences gene expression
Author:
Publisher
Springer Science and Business Media LLC
Subject
Genetics,Molecular Biology,Molecular Medicine
Link
http://www.nature.com/articles/gt201481.pdf
Reference47 articles.
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2. Ziady AG, Ferkol T, Dawson DV, Perlmutter DH, Davis PB . Chain length of the polylysine in receptor-targeted gene transfer complexes affects duration of reporter gene expression both in vitro and in vivo. J Biol Chem 1999; 274: 4908–4916.
3. Merdan T, Kunath K, Petersen H, Bakowsky U, Voigt KH, Kopecek J et al. PEGylation of poly(ethylene imine) affects stability of complexes with plasmid DNA under in vivo conditions in a dose-dependent manner after intravenous injection into mice. Bioconjug Chem 2005; 16: 785–792.
4. Ogris M, Brunner S, Schuller S, Kircheis R, Wagner E . PEGylated DNA/transferrin-PEI complexes: reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery. Gene Ther 1999; 6: 595–605.
5. Peracchia MT, Fattal E, Desmaele D, Besnard M, Noel JP, Gomis JM et al. Stealth PEGylated polycyanoacrylate nanoparticles for intravenous administration and splenic targeting. J Cont Rel 1999; 60: 121–128.
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