Untangling tau hyperphosphorylation in drug design for neurodegenerative diseases
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
http://www.nature.com/articles/nrd2111.pdf
Reference164 articles.
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2. Buee, L., Bussiere, T., Buee-Scherrer, V., Delacourte, A. & Hof, P. R. Tau protein isoforms, phosphorylation and role in neurodegenerative disorders. Brain Res. Rev. 33, 95–130 (2000).
3. Anderton, B. H. et al. Sites of phosphorylation in tau and factors affecting their regulation. Biochem. Soc. Symp. 67, 73–80 (2001).
4. Hardy, J. The relationship between amyloid and tau. J. Mol. Neurosci. 20, 203–206 (2003).
5. SantaCruz, K. et al. Tau suppression in a neurodegenerative mouse model improves memory function. Science 309, 476–481 (2005). Shows that after the suppression of transgenic tau, memory function recovered and neuron numbers stabilized, but suggests that NFTs are not sufficient to cause cognitive decline or neuronal death in the transgenic model used.
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