Gene–environment-wide association studies: emerging approaches
Author:
Publisher
Springer Science and Business Media LLC
Subject
Genetics(clinical),Genetics,Molecular Biology
Link
http://www.nature.com/articles/nrg2764.pdf
Reference172 articles.
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2. Le Marchand, L. & Wilkens, L. R. Design considerations for genomic association studies: importance of gene–environment interactions. Cancer Epidemiol. Biomarkers Prev. 17, 263–267 (2008).
3. Kraft, P., Yen, Y. C., Stram, D. O., Morrison, J. & Gauderman, W. J. Exploiting gene–environment interaction to detect genetic associations. Hum. Hered. 63, 111–119 (2007).
4. Hunter, D. J. Gene–environment interactions in human diseases. Nature Rev. Genet. 6, 287–298 (2005). An excellent Review of the basic principles of epidemiological study designs for G×E interactions in the pre-GWA studies era. Among other insights, the author argues that G×E findings can 'point the finger' towards the causal constituent of a complex mixture.
5. Greene, C. S., Penrod, N. M., Williams, S. M. & Moore, J. H. Failure to replicate a genetic association may provide important clues about genetic architecture. PLoS ONE 4, e5639 (2009).
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