An APP inhibitory domain containing the Flemish mutation residue modulates γ-secretase activity for Aβ production
Author:
Publisher
Springer Science and Business Media LLC
Subject
Molecular Biology,Structural Biology
Link
http://www.nature.com/articles/nsmb.1743.pdf
Reference59 articles.
1. Hardy, J. & Allsop, D. Amyloid deposition as the central event in the etiology of Alzheimer's disease. Trends Pharmacol. Sci. 12, 383–388 (1991).
2. Jarrett, J.T., Berger, E.P. & Lansbury, P.T., Jr. The C-terminus of the β protein is critical in amyloidogenesis. Ann. NY Acad. Sci. 695, 144–148 (1993).
3. Zhao, G. et al. Identification of a new presenilin-dependent ζ-cleavage site within the transmembrane domain of amyloid precursor protein. J. Biol. Chem. 279, 50647–50650 (2004).
4. Sastre, M. et al. Presenilin-dependent γ-secretase processing of β-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch. EMBO Rep. 2, 835–841 (2001).
5. Cao, X. & Sudhof, T.C. A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60. Science 293, 115–120 (2001).
Cited by 84 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. The Large Ectodomain of APP Prevents APP from being Directly Cleaved by γ-Secretase;Frontiers in Bioscience-Landmark;2024-02-21
2. APP substrate ectodomain defines amyloid‐β peptide length by restraining γ‐secretase processivity and facilitating product release;The EMBO Journal;2023-10-18
3. APP substrate ectodomain defines Aβ length by restraining γ-secretase processivity and facilitating product release;2023-09-13
4. Permissive Conformations of a Transmembrane Helix Allow Intramembrane Proteolysis by γ-Secretase;Journal of Molecular Biology;2023-09
5. APP-BACE1 Interaction and Intracellular Localization Regulate Aβ Production in iPSC-Derived Cortical Neurons;Cellular and Molecular Neurobiology;2023-06-24
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3