Mechanistic Investigations of the Mitochondrial Complex I Inhibitor Rotenone in the Context of Pharmacological and Safety Evaluation

Author:

Heinz Sabrina,Freyberger Alexius,Lawrenz Bettina,Schladt Ludwig,Schmuck Gabriele,Ellinger-Ziegelbauer Heidrun

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Reference74 articles.

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2. Palmer, G., Horgan, D. J., Tisdale, H., Singer, T. P. & Beinert, H. Studies on the respiratory chain-linked reduced nicotinamide adenine dinucleotide dehydrogenase. XIV. Location of the sites of inhibition of rotenone, barbiturates, and piericidin by means of electron paramagnetic resonance spectroscopy. J Biol Chem 243, 844–847 (1968).

3. Li, N. et al. Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production. J Biol Chem 278, 8516–8525, doi: 10.1074/jbc.M210432200 (2003).

4. Fato, R. et al. Differential effects of mitochondrial Complex I inhibitors on production of reactive oxygen species. Biochim Biophys Acta 1787, 384–392, doi: 10.1016/j.bbabio.2008.11.003 (2009).

5. Brinkley, B. R., Barham, S. S., Barranco, S. C. & Fuller, G. M. Rotenone inhibition of spindle microtubule assembly in mammalian cells. Exp Cell Res 85, 41–46 (1974).

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