Should LHRH therapy be continued in patients receiving abiraterone acetate?

Author:

Ah-Thiane LoicORCID,Supiot Stéphane

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Urology,Oncology

Reference5 articles.

1. Ohlmann CH, Jäschke M, Jaehnig P, Krege S, Gschwend J, Rexer H, et al. LHRH sparing therapy in patients with chemotherapy-naïve, mCRPC treated with abiraterone acetate plus prednisone: results of the randomized phase II SPARE trial. Prostate Cancer Prostatic Dis. 2022. https://doi.org/10.1038/s41391-022-00533-6

2. Supiot S, Campion L, Pommier P, Dore M, Palpacuer C, Racadot S, et al. Combined abiraterone acetate plus prednisone, salvage prostate bed radiotherapy and LH-RH agonists (CARLHA-GEP12) in biochemically-relapsing prostate cancer patients following prostatectomy: A phase I study of the GETUG/GEP. Oncotarget. 2018;9:22147–22157. https://doi.org/10.18632/oncotarget.25189

3. Maluf FC, Schutz FA, Cronemberger EH, Luz MA, Martins SPS, Muniz DQB, et al. A phase 2 randomized clinical trial of abiraterone plus ADT, apalutamide, or abiraterone and apalutamide in patients with advanced prostate cancer with non-castrate testosterone levels (LACOG 0415). Eur J Cancer. 2021;158:63–71. https://doi.org/10.1016/j.ejca.2021.08.032

4. Mariani S, Salvatori L, Basciani S, Arizzi M, Franco G, Petrangeli E, et al. Expression and cellular localization of follicle-stimulating hormone receptor in normal human prostate, benign prostatic hyperplasia and prostate cancer. J Urol. 2006;175:2072–7. https://doi.org/10.1016/S0022-5347(06)00273-4

5. Radu A, Pichon C, Camparo P, Antoine M, Allory Y, Couvelard A, et al. Expression of follicle-stimulating hormone receptor in tumor blood vessels. N Engl J Med. 2010;363:1621–30. https://doi.org/10.1056/NEJMoa1001283

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