Abstract
Abstract
Background/objectives
Based on the SPARTAN and TITAN studies, apalutamide is approved for patients with nonmetastatic castration-resistant and metastatic castration-sensitive prostate cancer. Skin rash was a common adverse reaction across indications. We hypothesized that earlier identification and intervention could improve rash outcomes.
Subjects/methods
A prespecified rash management guide outlining recommended skin care practices was provided to all patients enrolled in Apa-RP (NCT04523207). Rash-related safety data from Apa-RP were compared descriptively with data from SPARTAN and TITAN.
Results
Patients in Apa-RP experienced improved rash-related outcomes vs those in SPARTAN and TITAN.
Conclusions
Increased vigilance and proactive management may reduce the incidence, severity, and duration of rash during apalutamide treatment.
Funder
Janssen Scientific Affairs
Publisher
Springer Science and Business Media LLC
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