A Rieske oxygenase/epoxide hydrolase-catalysed reaction cascade creates oxygen heterocycles in mupirocin biosynthesis
Author:
Publisher
Springer Science and Business Media LLC
Subject
Process Chemistry and Technology,Biochemistry,Bioengineering,Catalysis
Link
http://www.nature.com/articles/s41929-018-0183-5.pdf
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3. Bridwell-Rabb, J., Kang, G., Zhong, A., Liu, H. W. & Drennan, C. L. An HD domain phosphohydrolase active site tailored for oxetanocin-A biosynthesis. Proc. Natl Acad. Sci. USA 113, 13750–13755 (2016).
4. Fuller, A. T. et al. Pseudomonic acid: an antibiotic produced by Pseudomonas fluorescens. Nature 234, 416–417 (1971).
5. Thomas, C. M., Hothersall, J., Willis, C. L. & Simpson, T. J. Resistance to and synthesis of the antibiotic mupirocin. Nat. Rev. Microbiol. 8, 281–289 (2010).
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