Efficient reductive desymmetrization of bulky 1,3-cyclodiketones enabled by structure-guided directed evolution of a carbonyl reductase
Author:
Publisher
Springer Science and Business Media LLC
Subject
Process Chemistry and Technology,Biochemistry,Bioengineering,Catalysis
Link
http://www.nature.com/articles/s41929-019-0347-y.pdf
Reference67 articles.
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4. Díaz-Rodríguez, A., Iglesias-Fernández, J., Rovira, C. & Gotor-Fernández, V. Enantioselective preparation of δ-valerolactones with horse liver alcohol dehydrogenase. ChemCatChem 6, 977–980 (2014).
5. Skoupi, M., Vaxelaire, C., Strohmann, C., Christmann, M. & Niemeyer, C. M. Enantiogroup-differentiating biocatalytic reductions of prochiral Cs-symmetrical dicarbonyl compounds to meso Compounds. Chem. Eur. J. 21, 8701–8705 (2015).
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