Knockout mice: a paradigm shift in modern immunology
Author:
Publisher
Springer Science and Business Media LLC
Subject
Energy Engineering and Power Technology,Fuel Technology
Link
http://www.nature.com/articles/nri35095551.pdf
Reference123 articles.
1. Maslow, A. H. Psychology of Science: A Reconnaissance (Harper & Row, New York, 1966).
2. Koller, B. H. & Smithies, O. Altering genes in animals by gene targeting. Annu. Rev. Immunol. 10, 705–730 (1992).
3. Koller, B. H., Marrack, P., Kappler, J. W. & Smithies, O. Normal development of mice deficient in β2M, MHC class I proteins, and CD8+ T cells. Science 248,1227–1230 (1990).
4. Zijlstra, M. et al. β2-microglobulin deficient mice lack CD4−8+ cytolytic T cells. Nature 344, 742–746 (1990).References 3 and 4 were the first reports of knockout mice with relevance to immunology.
5. Fung-Leung, W. P. et al. CD8 is needed for development of cytotoxic T cells but not helper T cells. Cell 65, 443–449 (1991).
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